Publications

Publications

2016

Afawi, Z., K. L. Oliver, S. Kivity, A. Mazarib, I. Blatt, M. Y. Neufeld, K. L. Helbig, H. Goldberg-Stern, A. J. Misk, R. Straussberg, S. Walid, M. Mahajnah, T. Lerman-Sagie, B. Ben-Zeev, E. Kahana, R. Masalha, U. Kramer, D. Ekstein, Z. Shorer, R. H. Wallace, M. Mangelsdorf, J. N. MacPherson, G. L. Carvill, H. C. Mefford, G. D. Jackson, I. E. Scheffer, M. Bahlo, J. Gecz, S. E. Heron, M. Corbett, J. C. Mulley, L. M. Dibbens, A. D. Korczyn and S. F. Berkovic. "Multiplex families with epilepsy: Success of clinical and molecular genetic characterization." Neurology (2016)

Arthur, A., D. Cakouros, L. Cooper, T. Nguyen, S. Isenmann, A. C. Zannettino, C. A. Glackin and S. Gronthos. "Twist-1 Enhances Bone Marrow Mesenchymal Stromal Cell Support of Hematopoiesis by Modulating CXCL12 Expression." Stem Cells 34: 504-509. (2016)

Aurelio, L., C. V. Scullino, M. R. Pitman, A. Sexton, V. Oliver, L. Davies, R. J. Rebello, L. Furic, D. J. Creek, S. M. Pitson and B. L. Flynn. "From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)." J Med Chem 59: 965-984. (2016)

Betterman, K. L. and N. L. Harvey. "The lymphatic vasculature: development and role in shaping immunity." Immunol Rev 271: 276-292. (2016)

Camera, D., H. A. Coleman, H. C. Parkington, T. A. Jenkins, D. V. Pow, N. Boase, S. Kumar and P. Poronnik. "Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice." Behav Brain Res 303: 176-181. (2016)

Christo, S. N., K. R. Diener, J. Manavis, M. A. Grimbaldeston, A. Bachhuka, K. Vasilev and J. D. Hayball. "Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses." Sci Rep 6: 20635. (2016)

Clarke, J. N., L. K. Davies, J. K. Calvert, B. L. Gliddon, W. H. Shujari, A. L. Aloia, K. J. Helbig, M. R. Beard, S. M. Pitson and J. M. Carr. "Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses." J Gen Virol 97: 95-109. (2016)

Deininger, M. W., J. G. Hodgson, N. P. Shah, J. E. Cortes, D. W. Kim, F. E. Nicolini, M. Talpaz, M. Baccarani, M. C. Muller, J. Li, W. T. Parker, S. Lustgarten, T. Clackson, F. G. Haluska, F. Guilhot, H. M. Kantarjian, S. Soverini, A. Hochhaus, T. P. Hughes, V. M. Rivera and S. Branford. "Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients." Blood 127: 703-712. (2016)

Dimasi, D. P., S. M. Pitson and C. S. Bonder. "Examining the role of sphingosine kinase-2 in the regulation of endothelial cell barrier integrity." Microcirculation (2016)

Galluzzi, L., A. Lopez-Soto, S. Kumar and G. Kroemer. "Caspases Connect Cell-Death Signaling to Organismal Homeostasis." Immunity 44: 221-231. (2016)

Harper, R. L., A. M. Reynolds, C. S. Bonder and P. N. Reynolds. "BMPR2 gene therapy for PAH acts via Smad and non-Smad signalling." Respirology (2016)

Kazenwadel, J. and N. L. Harvey. "Morphogenesis of the lymphatic vasculature: A focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels." Dev Dyn 245: 209-219. (2016)

Latham, S., P. A. Bartley, B. Budgen, D. M. Ross, E. Hughes, S. Branford, D. White, T. P. Hughes and A. A. Morley. "BCR-ABL1 expression, RT-qPCR and treatment decisions in chronic myeloid leukaemia." J Clin Pathol (2016)

Lewinsohn, M., A. L. Brown, L. M. Weinel, C. Phung, G. Rafidi, M. K. Lee, A. W. Schreiber, J. Feng, M. Babic, C. E. Chong, Y. Lee, A. Yong, G. K. Suthers, N. Poplawski, M. Altree, K. Phillips, L. Jaensch, M. Fine, R. J. D'Andrea, I. D. Lewis, B. C. Medeiros, D. A. Pollyea, M. C. King, T. Walsh, S. Keel, A. Shimamura, L. A. Godley, C. N. Hahn, J. E. Churpek and H. S. Scott. "Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies." Blood 127: 1017-1023. (2016)

Liapis, V., I. Zinonos, A. Labrinidis, S. Hay, V. Ponomarev, V. Panagopoulos, A. Zysk, M. DeNichilo, W. Ingman, G. J. Atkins, D. M. Findlay, A. C. Zannettino and A. Evdokiou. "Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models." Cancer Med (2016)

Lim, C. X., M. G. Ricos, L. M. Dibbens and S. E. Heron. "KCNT1 mutations in seizure disorders: the phenotypic spectrum and functional effects." J Med Genet (2016)

Ling, K. H., P. J. Brautigan, S. Moore, R. Fraser, P. S. Cheah, J. M. Raison, M. Babic, Y. K. Lee, T. Daish, D. M. Mattiske, J. R. Mann, D. L. Adelson, P. Q. Thomas, C. N. Hahn and H. S. Scott. "Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain." Genomics (2016)

Lynch, J. R., H. Yi, D. A. Casolari, F. Voli, E. Gonzales-Aloy, T. K. Fung, B. Liu, A. Brown, T. Liu, M. Haber, M. D. Norris, I. D. Lewis, C. W. So, R. J. D'Andrea and J. Y. Wang. "Gaq signaling is required for the maintenance of MLL-AF9 induced AML." Leukemia (2016)

Parker, W. T., D. T. Yeung, A. L. Yeoman, H. K. Altamura, B. A. Jamison, C. R. Field, J. G. Hodgson, S. Lustgarten, V. M. Rivera, T. P. Hughes and S. Branford. "The impact of multiple low-level BCR-ABL1 mutations on response to ponatinib." Blood (2016)

Ricos, M. G., B. L. Hodgson, T. Pippucci, A. Saidin, Y. S. Ong, S. E. Heron, L. Licchetta, F. Bisulli, M. A. Bayly, J. Hughes, S. Baldassari, F. Palombo, G. Epilepsy Electroclinical Study, M. Santucci, S. Meletti, S. F. Berkovic, G. Rubboli, P. Q. Thomas, I. E. Scheffer, P. Tinuper, J. Geoghegan, A. W. Schreiber and L. M. Dibbens. "Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy." Ann Neurol 79: 120-131. (2016)

Tran, H. B., J. Barnawi, M. Ween, R. Hamon, E. Roscioli, G. Hodge, P. N. Reynolds, S. M. Pitson, L. T. Davies, R. Haberberger and S. Hodge. "Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720." J Leukoc Biol (2016)

Wiszniak, S., N. Harvey and Q. Schwarz. "Cell autonomous roles of Nedd4 in craniofacial bone formation." Dev Biol 410: 98-107. (2016)

 

2015

Arthur, A., D. Cakouros, L. Cooper, T. Nguyen, S. Isenmann, A. C. Zannettino, C. A. Glackin and S. Gronthos. "Twist-1 Enhances Bone Marrow Mesenchymal Stromal Cell Support of Hematopoiesis by Modulating CXCL12 Expression." Stem Cells 34: 504-509. (2016)

Clarke, J. N., L. K. Davies, J. K. Calvert, B. L. Gliddon, W. H. Shujari, A. L. Aloia, K. J. Helbig, M. R. Beard, S. M. Pitson and J. M. Carr. "Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses." J Gen Virol 97: 95-109. (2016)

Deininger, M. W., J. G. Hodgson, N. P. Shah, J. E. Cortes, D. W. Kim, F. E. Nicolini, M. Talpaz, M. Baccarani, M. C. Muller, J. Li, W. T. Parker, S. Lustgarten, T. Clackson, F. G. Haluska, F. Guilhot, H. M. Kantarjian, S. Soverini, A. Hochhaus, T. P. Hughes, V. M. Rivera and S. Branford. "Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients." Blood 127: 703-712. (2016)

Ricos, M. G., B. L. Hodgson, T. Pippucci, A. Saidin, Y. S. Ong, S. E. Heron, L. Licchetta, F. Bisulli, M. A. Bayly, J. Hughes, S. Baldassari, F. Palombo, G. Epilepsy Electroclinical Study, M. Santucci, S. Meletti, S. F. Berkovic, G. Rubboli, P. Q. Thomas, I. E. Scheffer, P. Tinuper, J. Geoghegan, A. W. Schreiber and L. M. Dibbens. "Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy." Ann Neurol 79: 120-131. (2016)

Wiszniak, S., N. Harvey and Q. Schwarz. "Cell autonomous roles of Nedd4 in craniofacial bone formation." Dev Biol 410: 98-107. (2016)

Abbott, S., P. Hewett, J. Cooper and A. Ruszkiewicz. "Idiopathic myointimal hyperplasia of the mesenteric veins: a rare differential to be considered in idiopathic colitis." ANZ J Surg (2015)

Aloia, A. L., A. M. Abraham, C. S. Bonder, S. M. Pitson and J. M. Carr. "Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs." Mediators Inflamm 2015: 509306. (2015)

Aloia, A. L., N. S. Eyre, S. Black, S. J. Bent, A. Gaeguta, Z. Guo, S. K. Narayana, R. Chase, S. Locarnini, J. M. Carr, J. A. Howe and M. R. Beard. "Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations." Antivir Ther 20: 271-280. (2015)

Angeli, V. and N. L. Harvey. "Lymphatic Vessels at the Heart of the Matter." Cell Metab 22: 56-58. (2015)

Bagnall, R. D., D. E. Crompton, S. Petrovski, L. Lam, C. Cutmore, S. I. Garry, L. G. Sadleir, L. M. Dibbens, A. Cairns, S. Kivity, Z. Afawi, B. M. Regan, J. Duflou, S. F. Berkovic, I. E. Scheffer and C. Semsarian. "Exome-based analysis of cardiac arrhythmia, respiratory control and epilepsy genes in sudden unexpected death in epilepsy." Ann Neurol (2015)

Baker, E. K., S. Taylor, A. Gupte, P. P. Sharp, M. Walia, N. C. Walsh, A. C. Zannettino, A. M. Chalk, C. J. Burns and C. R. Walkley. "BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells." Sci Rep 5: 10120. (2015)

Barnawi, J., H. Tran, H. Jersmann, S. Pitson, E. Roscioli, G. Hodge, R. Meech, R. Haberberger and S. Hodge. "Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD)." PLoS One 10: e0122771. (2015)

Bartley, P. A., S. Latham, B. Budgen, D. M. Ross, E. Hughes, S. Branford, D. White, T. P. Hughes and A. A. Morley. "A DNA real-time quantitative PCR method suitable for routine monitoring of low levels of minimal residual disease in chronic myeloid leukemia." J Mol Diagn 17: 185-192. (2015)

Basnet, S. K., S. Diab, R. Schmid, M. Yu, Y. Yang, T. A. Gillam, T. Teo, P. Li, T. Peat, H. Albrecht and S. Wang. "Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2." Mol Pharmacol 88: 935-948. (2015)

Belle, L., N. Ali, A. Lonic, X. Li, J. L. Paltridge, S. Roslan, D. Herrmann, J. R. Conway, F. K. Gehling, A. G. Bert, L. A. Crocker, A. Tsykin, G. Farshid, G. J. Goodall, P. Timpson, R. J. Daly and Y. Khew-Goodall. "The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking." Sci Signal 8: ra18. (2015)

Bergot, A. S., N. Monnet, S. Le Tran, D. Mittal, J. Al-Kouba, R. J. Steptoe, M. A. Grimbaldeston, I. H. Frazer and J. W. Wells. "HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions." Immunol Cell Biol 93: 540-547. (2015)

Boase, N. A. and S. Kumar. "NEDD4: The founding member of a family of ubiquitin-protein ligases." Gene 557: 113-122. (2015)

Bonder, C. S. and S. M. Pitson. "Sphingolipids--who's controlling who in disease?" Immunol Cell Biol 93: 767-768. (2015)

Bracken, C. P., Y. Khew-Goodall and G. J. Goodall. "Network-Based Approaches to Understand the Roles of miR-200 and Other microRNAs in Cancer." Cancer Res 75: 2594-2599. (2015)

Broughton, S. E., T. L. Nero, U. Dhagat, W. L. Kan, T. R. Hercus, D. Tvorogov, A. F. Lopez and M. W. Parker. "The betac receptor family - Structural insights and their functional implications." Cytokine 74: 247-258. (2015)

Calvert, J. K., K. J. Helbig, D. Dimasi, M. Cockshell, M. R. Beard, S. M. Pitson, C. S. Bonder and J. M. Carr. "Dengue Virus Infection of Primary Endothelial Cells Induces Innate Immune Responses, Changes in Endothelial Cells Function and Is Restricted by Interferon-Stimulated Responses." J Interferon Cytokine Res 35: 654-665. (2015)

Canlas, J., P. Holt, A. Carroll, S. Rix, P. Ryan, L. Davies, D. Matusica, S. M. Pitson, C. F. Jessup, I. L. Gibbins and R. V. Haberberger. "Sphingosine kinase 2-deficiency mediated changes in spinal pain processing." Front Mol Neurosci 8: 29. (2015)

Chandrasegaram, M. D., A. Shah, J. W. Chen, A. Ruszkiewicz, D. S. Astill, G. England, R. S. Raju, E. L. Neo, P. M. Dolan, C. P. Tan, M. Brooke-Smith, T. Wilson, R. T. Padbury and C. S. Worthley. "Oestrogen hormone receptors in focal nodular hyperplasia." HPB (Oxford) 17: 502-507. (2015)

Cheong, C. M., A. W. Chow, S. Fitter, D. R. Hewett, S. K. Martin, S. A. Williams, L. B. To, A. C. Zannettino and K. Vandyke. "Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo." Exp Cell Res 332: 24-38. (2015)

Christo, S. N., K. R. Diener, R. E. Nordon, M. P. Brown, H. J. Griesser, K. Vasilev, F. C. Christo and J. D. Hayball. "Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus." Sci Rep 5: 7760. (2015)

Conn, S. J., K. A. Pillman, J. Toubia, V. M. Conn, M. Salmanidis, C. A. Phillips, S. Roslan, A. W. Schreiber, P. A. Gregory and G. J. Goodall. "The RNA binding protein quaking regulates formation of circRNAs." Cell 160: 1125-1134. (2015)

Cursons, J., K. J. Leuchowius, M. Waltham, E. Tomaskovic-Crook, M. Foroutan, C. P. Bracken, A. Redfern, E. J. Crampin, I. Street, M. J. Davis and E. W. Thompson. "Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines." Cell Commun Signal 13: 26. (2015)

Denton, D. and S. Kumar. "Studying Apoptosis in Drosophila." Cold Spring Harb Protoc 2015: 609-613. (2015)

Denton, D. and S. Kumar. "Using Synthetic Peptide Substrates to Measure Drosophila Caspase Activity." Cold Spring Harb Protoc 2015: 671-673. (2015)

Denton, D. and S. Kumar. "Analyzing the Response of RNAi-Treated Drosophila Cells to Death Stimuli by Quantitative Real-Time Polymerase Chain Reaction." Cold Spring Harb Protoc 2015: 666-670. (2015)

Denton, D. and S. Kumar. "Immunostaining Using an Antibody against Active Caspase-3 to Detect Apoptotic Cells in Drosophila." Cold Spring Harb Protoc 2015: 576-579. (2015)

Denton, D. and S. Kumar. "Using the vital dye acridine orange to detect dying cells in Drosophila." Cold Spring Harb Protoc 2015: 572-575. (2015)

Denton, D. and S. Kumar. "Terminal Deoxynucleotidyl Transferase (TdT)-Mediated dUTP Nick-End Labeling (TUNEL) for Detection of Apoptotic Cells in Drosophila." Cold Spring Harb Protoc 2015: 568-571. (2015)

Denton, D., T. Xu and S. Kumar. "Autophagy as a pro-death pathway." Immunol Cell Biol 93: 35-42. (2015)

Enjeti, A., N. Granter, A. Ashraf, L. Fletcher, S. Branford, P. Rowlings and S. Dooley. "A longitudinal evaluation of performance of automated BCR-ABL1 quantitation using cartridge-based detection system." Pathology 47: 570-574. (2015)

Etemadi, N., M. Chopin, H. Anderton, M. C. Tanzer, J. A. Rickard, W. Abeysekera, C. Hall, S. K. Spall, B. Wang, Y. Xiong, T. Hla, S. M. Pitson, C. S. Bonder, W. W. Wong, M. Ernst, G. K. Smyth, D. L. Vaux, S. L. Nutt, U. Nachbur and J. Silke. "TRAF2 regulates TNF and NF-kappaB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1." Elife 4: (2015)

Fisher, J. N., M. Terao, M. Fratelli, M. Kurosaki, G. Paroni, A. Zanetti, M. Gianni, M. Bolis, M. Lupi, A. Tsykin, G. J. Goodall and E. Garattini. "MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells." Oncotarget 6: 13176-13200. (2015)

Forristal, C. E., A. L. Brown, F. M. Helwani, I. G. Winkler, B. Nowlan, V. Barbier, R. J. Powell, G. A. Engler, S. M. Diakiw, A. C. Zannettino, S. Martin, D. Pattabiraman, R. J. D'Andrea, I. D. Lewis and J. P. Levesque. "Hypoxia inducible factor (HIF)-2alpha accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML." Leukemia 29: 2075-2085. (2015)

Fung, K. Y., B. Tabor, M. J. Buckley, I. K. Priebe, L. Purins, C. Pompeia, G. V. Brierley, T. Lockett, P. Gibbs, J. Tie, P. McMurrick, J. Moore, A. Ruszkiewicz, E. Nice, T. E. Adams, A. Burgess and L. J. Cosgrove. "Blood-based protein biomarker panel for the detection of colorectal cancer." PLoS One 10: e0120425. (2015)

Gagliardi, L., N. Nataren, J. Feng, A. W. Schreiber, C. N. Hahn, L. S. Conwell, D. Coman and H. S. Scott. "Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss." Am J Med Genet A 167A: 1872-1876. (2015)

Galluzzi, L., F. Pietrocola, J. M. Bravo-San Pedro, R. K. Amaravadi, E. H. Baehrecke, F. Cecconi, P. Codogno, J. Debnath, D. A. Gewirtz, V. Karantza, A. Kimmelman, S. Kumar, B. Levine, M. C. Maiuri, S. J. Martin, J. Penninger, M. Piacentini, D. C. Rubinsztein, H. U. Simon, A. Simonsen, A. M. Thorburn, G. Velasco, K. M. Ryan and G. Kroemer. "Autophagy in malignant transformation and cancer progression." EMBO J 34: 856-880. (2015)

Gan, Z. Y., S. Fitter, K. Vandyke, L. B. To, A. C. Zannettino and S. K. Martin. "The effect of the dual PI3K and mTOR inhibitor BEZ235 on tumour growth and osteolytic bone disease in multiple myeloma." Eur J Haematol 94: 343-354. (2015)

Gargett, T. and M. P. Brown. "Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2." Cytotherapy 17: 487-495. (2015)

Gargett, T., C. K. Fraser, G. Dotti, E. S. Yvon and M. P. Brown. "BRAF and MEK inhibition variably affect GD2-specific chimeric antigen receptor (CAR) T-cell function in vitro." J Immunother 38: 12-23. (2015)

Goel, P., J. A. Manning and S. Kumar. "NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins." Gene 557: 1-10. (2015)

Green, T. J., P. Speck, L. Geng, D. Raftos, M. R. Beard and K. J. Helbig. "Oyster viperin retains direct antiviral activity and its transcription occurs via a signalling pathway involving a heat-stable hemolymph protein." J Gen Virol (2015)

Grimbaldeston, M. A. "Mast cell-MrgprB2: sensing secretagogues or a means to overreact?" Immunol Cell Biol 93: 221-223. (2015)

Gupte, A., E. K. Baker, S. S. Wan, E. Stewart, A. Loh, A. A. Shelat, C. M. Gould, A. M. Chalk, S. Taylor, K. Lackovic, A. Karlstrom, A. J. Mutsaers, J. Desai, P. B. Madhamshettiwar, A. C. Zannettino, C. Burns, D. C. Huang, M. A. Dyer, K. J. Simpson and C. R. Walkley. "Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma." Clin Cancer Res 21: 3216-3229. (2015)

Hahn, C. N., P. J. Brautigan, C. E. Chong, A. Janssan, P. Venugopal, Y. Lee, A. E. Tims, M. S. Horwitz, M. Klingler-Hoffmann and H. S. Scott. "Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia." Leukemia 29: 1795-1797. (2015)

Hahn, C. N., D. M. Ross, J. Feng, A. Beligaswatte, D. K. Hiwase, W. T. Parker, M. Ho, M. Zawitkowski, K. L. Ambler, G. D. Cheetham, Y. K. Lee, M. Babic, C. M. Butcher, G. A. Engler, A. L. Brown, R. J. D'Andrea, I. D. Lewis, A. W. Schreiber, L. B. To and H. S. Scott. "A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone." Leukemia 29: 2101-2104. (2015)

Hahn, C. N., P. Venugopal, H. S. Scott and D. K. Hiwase. "Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy." Immunol Rev 263: 257-278. (2015)

Hare, L. M., Q. Schwarz, S. Wiszniak, R. Gurung, K. G. Montgomery, C. A. Mitchell and W. A. Phillips. "Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects." Dev Biol 404: 14-26. (2015)

He, S. Z., S. Busfield, D. S. Ritchie, M. S. Hertzberg, S. Durrant, I. D. Lewis, P. Marlton, A. J. McLachlan, I. Kerridge, K. F. Bradstock, G. Kennedy, A. W. Boyd, T. M. Yeadon, A. F. Lopez, H. S. Ramshaw, H. Iland, S. Bamford, M. Barnden, M. DeWitte, R. Basser and A. W. Roberts. "A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia." Leuk Lymphoma 56: 1406-1415. (2015)

Hersh, E. M., M. Del Vecchio, M. P. Brown, R. Kefford, C. Loquai, A. Testori, S. Bhatia, R. Gutzmer, R. Conry, A. Haydon, C. Robert, S. Ernst, J. Homsi, J. J. Grob, K. Kendra, S. S. Agarwala, M. Li, A. Clawson, C. Brachmann, M. Karnoub, I. Elias, M. F. Renschler and A. Hauschild. "A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naive patients with metastatic melanoma." Ann Oncol 26: 2267-2274. (2015)

Hu, Z., H. S. Scott, G. Qin, G. Zheng, X. Chu, L. Xie, D. L. Adelson, B. E. Oftedal, P. Venugopal, M. Babic, C. N. Hahn, B. Zhang, X. Wang, N. Li and C. Wei. "Revealing Missing Human Protein Isoforms Based on Ab Initio Prediction, RNA-seq and Proteomics." Sci Rep 5: 10940. (2015)

Jaehne, E. J., H. Ramshaw, X. Xu, E. Saleh, S. R. Clark, K. O. Schubert, A. Lopez, Q. Schwarz and B. T. Baune. "In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3zeta KO mouse model of schizophrenia-like disorders." Pharmacol Biochem Behav 138: 1-8. (2015)

Jorissen, R. N., M. Christie, D. Mouradov, A. Sakthianandeswaren, S. Li, C. Love, Z. Z. Xu, P. L. Molloy, I. T. Jones, S. McLaughlin, R. L. Ward, N. J. Hawkins, A. R. Ruszkiewicz, J. Moore, A. W. Burgess, D. Busam, Q. Zhao, R. L. Strausberg, L. Lipton, J. Desai, P. Gibbs and O. M. Sieber. "Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer." Br J Cancer 113: 979-988. (2015)

Kazenwadel, J., K. L. Betterman, C. E. Chong, P. H. Stokes, Y. K. Lee, G. A. Secker, Y. Agalarov, C. S. Demir, D. M. Lawrence, D. L. Sutton, S. P. Tabruyn, N. Miura, M. Salminen, T. V. Petrova, J. M. Matthews, C. N. Hahn, H. S. Scott and N. L. Harvey. "GATA2 is required for lymphatic vessel valve development and maintenance." J Clin Invest 125: 2979-2994. (2015)

Kazenwadel, J. and N. L. Harvey. "Morphogenesis of the lymphatic vasculature: A focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels." Dev Dyn (2015)

Komrokji, R. S., J. F. Seymour, A. W. Roberts, M. Wadleigh, L. B. To, R. Scherber, E. Turba, A. Dorr, J. Zhu, L. Wang, T. Granston, M. S. Campbell and R. A. Mesa. "Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis." Blood 125: 2649-2655. (2015)

Kopecki, Z., G. N. Yang, J. E. Jackson, E. L. Melville, M. P. Calley, D. F. Murrell, I. A. Darby, E. A. O'Toole, M. S. Samuel and A. J. Cowin. "Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression." Oncotarget 6: 36426-36440. (2015)

Kular, J., K. G. Scheer, N. T. Pyne, A. H. Allam, A. N. Pollard, A. Magenau, R. L. Wright, N. Kolesnikoff, P. A. Moretti, L. Wullkopf, F. C. Stomski, A. J. Cowin, J. M. Woodcock, M. A. Grimbaldeston, S. M. Pitson, P. Timpson, H. S. Ramshaw, A. F. Lopez and M. S. Samuel. "A Negative Regulatory Mechanism Involving 14-3-3zeta Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis." Dev Cell 35: 759-774. (2015)

Lawson, M. A., M. M. McDonald, N. Kovacic, W. Hua Khoo, R. L. Terry, J. Down, W. Kaplan, J. Paton-Hough, C. Fellows, J. A. Pettitt, T. Neil Dear, E. Van Valckenborgh, P. A. Baldock, M. J. Rogers, C. L. Eaton, K. Vanderkerken, A. R. Pettit, J. M. Quinn, A. C. Zannettino, T. G. Phan and P. I. Croucher. "Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche." Nat Commun 6: 8983. (2015)

Lee, E. M., D. Yee, S. J. Busfield, J. F. McManus, N. Cummings, G. Vairo, A. Wei, H. S. Ramshaw, J. A. Powell, A. F. Lopez, I. D. Lewis, M. N. McCall and R. B. Lock. "Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice." Haematologica 100: 914-926. (2015)

Lewinsohn, M., A. L. Brown, L. M. Weinel, C. Phung, G. Rafidi, M. K. Lee, A. W. Schreiber, J. Feng, M. Babic, C. E. Chong, Y. Lee, A. Yong, G. K. Suthers, N. Poplawski, M. Altree, K. Phillips, L. Jaensch, M. Fine, R. J. D'Andrea, I. D. Lewis, B. C. Medeiros, D. A. Pollyea, M. C. King, T. Walsh, S. Keel, A. Shimamura, L. A. Godley, C. N. Hahn, J. N. Churpek and H. S. Scott. "Novel germline DDX41 mutations define families with a lower age of MDS/AML onset, and lymphoid malignancies." Blood (2015)

Liapis, V., A. Labrinidis, I. Zinonos, S. Hay, V. Ponomarev, V. Panagopoulos, M. DeNichilo, W. Ingman, G. J. Atkins, D. M. Findlay, A. C. Zannettino and A. Evdokiou. "Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma." Cancer Lett 357: 160-169. (2015)

Lim, G. E., T. Albrecht, M. Piske, K. Sarai, J. T. Lee, H. S. Ramshaw, S. Sinha, M. A. Guthridge, A. Acker-Palmer, A. F. Lopez, S. M. Clee, C. Nislow and J. D. Johnson. "14-3-3zeta coordinates adipogenesis of visceral fat." Nat Commun 6: 7671. (2015)

Lim, G. E., T. Albrecht, M. Piske, K. Sarai, J. T. C. Lee, H. S. Ramshaw, S. Sinha, M. A. Guthridge, A. Acker-Palmer, A. F. Lopez, S. M. Clee, C. Nislow and J. D. Johnson. "14-3-3 zeta coordinates adipogenesis of visceral fat." Nature Communications 6: (2015)

Lim, S. L., Z. P. Qu, R. D. Kortschak, D. M. Lawrence, J. Geoghegan, A. L. Hempfling, M. Bergmann, C. C. Goodnow, C. J. Ormandy, L. Wong, J. Mann, H. S. Scott, D. Jamsai, D. L. Adelson and M. K. O'Bryan. "Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse." PLoS Genet 11: e1005782. (2015)

Lim, S. L., Z. P. Qu, R. D. Kortschak, D. M. Lawrence, J. Geoghegan, A. L. Hempfling, M. Bergmann, C. C. Goodnow, C. J. Ormandy, L. Wong, J. Mann, H. S. Scott, D. Jamsai, D. L. Adelson and M. K. O'Bryan. "HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse." PLoS Genet 11: e1005620. (2015)

Lim, Y. and S. Kumar. "A single cut to pyroptosis." Oncotarget 6: 36926-36927. (2015)

Lumb, R. and Q. Schwarz. "Sympathoadrenal neural crest cells: the known, unknown and forgotten?" Dev Growth Differ 57: 146-157. (2015)

Martin, S. K., S. Fitter, A. K. Dutta, M. P. Matthews, C. R. Walkley, M. N. Hall, M. A. Ruegg, S. Gronthos and A. C. Zannettino. "Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation." Stem Cells 33: 1359-1365. (2015)

Martin, S. K., Z. Y. Gan, S. Fitter, L. B. To and A. C. Zannettino. "The effect of the PI3K inhibitor BKM120 on tumour growth and osteolytic bone disease in multiple myeloma." Leuk Res 39: 380-387. (2015)

Milic, N. L., S. Davis, J. M. Carr, S. Isberg, M. R. Beard and K. J. Helbig. "Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus)." Dev Comp Immunol 51: 108-115. (2015)

Mina, M. M., F. Luciani, B. Cameron, R. A. Bull, M. R. Beard, D. Booth and A. R. Lloyd. "Resistance to hepatitis C virus: potential genetic and immunological determinants." Lancet Infect Dis 15: 451-460. (2015)

Moldenhauer, L. M., M. P. Cockshell, L. Frost, K. A. Parham, D. Tvorogov, L. Y. Tan, L. M. Ebert, K. Tooley, S. Worthley, A. F. Lopez and C. S. Bonder. "Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties." Stem Cell Res 14: 380-395. (2015)

Moller, R. S., S. E. Heron, L. H. Larsen, C. X. Lim, M. G. Ricos, M. A. Bayly, M. J. van Kempen, S. Klinkenberg, I. Andrews, K. Kelley, G. M. Ronen, D. Callen, J. M. McMahon, S. C. Yendle, G. L. Carvill, H. C. Mefford, R. Nabbout, A. Poduri, P. Striano, M. G. Baglietto, F. Zara, N. J. Smith, C. Pridmore, E. Gardella, M. Nikanorova, H. A. Dahl, P. Gellert, I. E. Scheffer, B. Gunning, B. Kragh-Olsen and L. M. Dibbens. "Mutations in KCNT1 cause a spectrum of focal epilepsies." Epilepsia 56: e114-120. (2015)

Mordaunt, D. A., L. C. McIntyre, H. Salvemini, A. Ibrahim, D. Bratkovic, D. Ketteridge, H. S. Scott, K. S. Kassahn and N. Smith. "Presentation of m.3243A>G (MT-TL1; tRNALeu) variant with focal neurology in infancy." Am J Med Genet A 167A: 2697-2701. (2015)

Mrozik, K. M., C. M. Cheong, D. Hewett, A. W. Chow, O. W. Blaschuk, A. C. Zannettino and K. Vandyke. "Therapeutic targeting of N-cadherin is an effective treatment for multiple myeloma." Br J Haematol 171: 387-399. (2015)

Muona, M., S. F. Berkovic, L. M. Dibbens, K. L. Oliver, S. Maljevic, M. A. Bayly, T. Joensuu, L. Canafoglia, S. Franceschetti, R. Michelucci, S. Markkinen, S. E. Heron, M. S. Hildebrand, E. Andermann, F. Andermann, A. Gambardella, P. Tinuper, L. Licchetta, I. E. Scheffer, C. Criscuolo, A. Filla, E. Ferlazzo, J. Ahmad, A. Ahmad, B. Baykan, E. Said, M. Topcu, P. Riguzzi, M. D. King, C. Ozkara, D. M. Andrade, B. A. Engelsen, A. Crespel, M. Lindenau, E. Lohmann, V. Saletti, J. Massano, M. Privitera, A. J. Espay, B. Kauffmann, M. Duchowny, R. S. Moller, R. Straussberg, Z. Afawi, B. Ben-Zeev, K. E. Samocha, M. J. Daly, S. Petrou, H. Lerche, A. Palotie and A. E. Lehesjoki. "A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy." Nat Genet 47: 39-46. (2015)

Narayana, S. K., K. J. Helbig, E. M. McCartney, N. S. Eyre, R. A. Bull, A. Eltahla, A. R. Lloyd and M. R. Beard. "The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry." J Biol Chem 290: 25946-25959. (2015)

Nguyen, T. M., A. Arthur, R. Panagopoulos, S. Paton, J. D. Hayball, A. C. Zannettino, L. E. Purton, K. Matsuo and S. Gronthos. "EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance." Stem Cells 33: 2838-2849. (2015)

Nguyen, T. V., A. Melville, S. Nath, C. Story, S. Howell, R. Sutton, A. Zannettino and T. Revesz. "Bone Marrow Recovery by Morphometry during Induction Chemotherapy for Acute Lymphoblastic Leukemia in Children." PLoS One 10: e0126233. (2015)

Nicolson, S., D. Denton and S. Kumar. "Ecdysone-mediated programmed cell death in Drosophila." Int J Dev Biol 59: 23-32. (2015)

Noll, J. E., K. Vandyke, D. R. Hewett, K. M. Mrozik, R. J. Bala, S. A. Williams, C. H. Kok and A. C. Zannettino. "PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma." J Hematol Oncol 8: 106. (2015)

Pal, B., Y. Chen, A. Bert, Y. Hu, J. M. Sheridan, T. Beck, W. Shi, K. Satterley, P. Jamieson, G. J. Goodall, G. J. Lindeman, G. K. Smyth and J. E. Visvader. "Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits." Breast Cancer Res 17: 85. (2015)

Panousis, C., U. Dhagat, K. M. Edwards, V. Rayzman, M. P. Hardy, H. Braley, G. M. Gauvreau, T. R. Hercus, S. Smith, R. Sehmi, L. McMillan, M. Dottore, B. J. McClure, L. J. Fabri, G. Vairo, A. F. Lopez, M. W. Parker, A. D. Nash, N. J. Wilson, M. J. Wilson and C. M. Owczarek. "CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors." MAbs e1119352. (2015)

Parham, K. A., J. R. Zebol, K. L. Tooley, W. Y. Sun, L. M. Moldenhauer, M. P. Cockshell, B. L. Gliddon, P. A. Moretti, G. Tigyi, S. M. Pitson and C. S. Bonder. "Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-gamma that regulates neoangiogenesis." FASEB J 29: 3638-3653. (2015)

Peintner, L., L. Dorstyn, S. Kumar, T. Aneichyk, A. Villunger and C. Manzl. "The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd." Cell Death Differ 22: 1803-1811. (2015)

Pitman, M. R., J. A. Powell, C. Coolen, P. A. Moretti, J. R. Zebol, D. H. Pham, J. W. Finnie, A. S. Don, L. M. Ebert, C. S. Bonder, B. L. Gliddon and S. M. Pitson. "A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties." Oncotarget 6: 7065-7083. (2015)

Quach, H., D. Joshua, J. Ho, J. Szer, A. Spencer, S. Harrison, P. Mollee, A. Roberts, N. Horvath, D. Talaulikar, B. To, A. Zannettino, R. Brown, L. Catley, B. Augustson, W. Jaksic, J. Gibson and H. M. Prince. "Treatment of patients with multiple myeloma who are not eligible for stem cell transplantation: position statement of the myeloma foundation of Australia Medical and Scientific Advisory Group." Intern Med J 45: 335-343. (2015)

Quach, H., D. Joshua, J. Ho, J. Szer, A. Spencer, S. J. Harrison, P. Mollee, A. W. Roberts, N. Horvath, D. Talulikar, B. To, A. Zannettino, R. Brown, L. Catley, B. Augustson, W. Jaksic, J. Gibson and H. M. Prince. "Treatment of patients with multiple myeloma who are eligible for stem cell transplantation: position statement of the Myeloma Foundation of Australia Medical and Scientific Advisory Group." Intern Med J 45: 94-105. (2015)

R, A. L. D., A. H. Staudacher, E. Bezak and M. P. Brown. "Autoradiography imaging in targeted alpha therapy with Timepix detector." Comput Math Methods Med 2015: 612580. (2015)

Ross, D. M., H. K. Altamura, C. N. Hahn, M. Nicola, A. L. Yeoman, M. R. Holloway, J. Geoghegan, J. Feng, A. W. Schreiber, S. Branford, S. Moore and H. S. Scott. "Delayed diagnosis leading to accelerated-phase chronic eosinophilic leukemia due to a cytogenetically cryptic, imatinib-responsive TNIP1-PDFGRB fusion gene." Leukemia (2015)

Ruan, C. S., F. H. Zhou, Z. Y. He, S. F. Wang, C. R. Yang, Y. J. Shen, Y. Guo, H. B. Zhao, L. Chen, D. Liu, J. Liu, B. T. Baune, Z. C. Xiao and X. F. Zhou. "Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors." Neuroscience 293: 12-22. (2015)

Sanij, E., J. Diesch, A. Lesmana, G. Poortinga, N. Hein, G. Lidgerwood, D. P. Cameron, J. Ellul, G. J. Goodall, L. H. Wong, A. S. Dhillon, N. Hamdane, L. I. Rothblum, R. B. Pearson, I. Haviv, T. Moss and R. D. Hannan. "A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes." Genome Res 25: 201-212. (2015)

Secker, G. A. and N. L. Harvey. "VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels." Dev Dyn 244: 323-331. (2015)

Shalini, S., L. Dorstyn, S. Dawar and S. Kumar. "Old, new and emerging functions of caspases." Cell Death Differ 22: 526-539. (2015)

Shalini, S., J. Puccini, C. H. Wilson, J. Finnie, L. Dorstyn and S. Kumar. "Caspase-2 protects against oxidative stress in vivo." Oncogene 34: 4995-5002. (2015)

Singhal, N., S. Vatandoust and M. P. Brown. "Phase II study evaluating efficacy and safety of everolimus with letrozole for management of advanced (unresectable or metastatic) non-small cell lung cancer after failure of platinum-based treatment: a preliminary analysis of toxicity." Cancer Chemother Pharmacol 75: 325-331. (2015)

Smith, E., H. M. Palethorpe, A. R. Ruszkiewicz, S. Edwards, D. A. Leach, T. J. Underwood, E. F. Need and P. A. Drew. "Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma." Dig Dis Sci (2015)

Takhar, H. S., N. Singhal, R. Gowda, M. Penniment, P. Takhar and M. P. Brown. "Phase I study evaluating the safety and efficacy of oral panobinostat in combination with radiotherapy or chemoradiotherapy in patients with inoperable stage III non-small-cell lung cancer." Anticancer Drugs 26: 1069-1077. (2015)

Teo, T., F. Lam, M. Yu, Y. Yang, S. K. Basnet, H. Albrecht, M. J. Sykes and S. Wang. "Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia." Mol Pharmacol 88: 380-389. (2015)

Teo, T., Y. Yang, M. Yu, S. K. Basnet, T. Gillam, J. Hou, R. M. Schmid, M. Kumarasiri, S. Diab, H. Albrecht, M. J. Sykes and S. Wang. "An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis." Eur J Med Chem 103: 539-550. (2015)

Teo, T., M. Yu, Y. Yang, T. Gillam, F. Lam, M. J. Sykes and S. Wang. "Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells." Cancer Lett 357: 612-623. (2015)

Thomas, M. L., P. J. Hewett, A. R. Ruszkiewicz and J. W. Moore. "Clinicopathological predictors of benefit from adjuvant chemotherapy for stage C colorectal cancer: Microsatellite unstable cases benefit." Asia Pac J Clin Oncol 11: 343-351. (2015)

Thomson, D. W., K. A. Pillman, M. L. Anderson, D. M. Lawrence, J. Toubia, G. J. Goodall and C. P. Bracken. "Assessing the gene regulatory properties of Argonaute-bound small RNAs of diverse genomic origin." Nucleic Acids Res 43: 470-481. (2015)

Tong, P. L., B. Roediger, N. Kolesnikoff, M. Biro, S. S. Tay, R. Jain, L. E. Shaw, M. A. Grimbaldeston and W. Weninger. "The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy." J Invest Dermatol 135: 84-93. (2015)

Tse, E., K. J. Helbig, K. Van der Hoek, E. M. McCartney, M. Van der Hoek, J. George and M. R. Beard. "Fatty Acids Induce a Pro-Inflammatory Gene Expression Profile in Huh-7 Cells That Attenuates the Anti-HCV Action of Interferon." J Interferon Cytokine Res 35: 392-400. (2015)

Tu, T., W. S. Mason, A. D. Clouston, N. A. Shackel, G. W. McCaughan, M. M. Yeh, E. R. Schiff, A. R. Ruszkiewicz, J. W. Chen, H. A. Harley, U. H. Stroeher and A. R. Jilbert. "Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection." J Viral Hepat 22: 737-753. (2015)

Uy, G. L., L. J. Costa, P. N. Hari, M. J. Zhang, J. X. Huang, K. C. Anderson, C. N. Bredeson, N. S. Callander, R. F. Cornell, M. A. Perez, A. Dispenzieri, C. O. Freytes, R. P. Gale, A. Garfall, M. A. Gertz, J. Gibson, M. Hamadani, H. M. Lazarus, M. E. Kalaycio, R. T. Kamble, M. A. Kharfan-Dabaja, A. Y. Krishnan, S. K. Kumar, R. A. Kyle, H. J. Landau, C. H. Lee, A. Maiolino, D. I. Marks, T. M. Mark, R. Munker, T. Nishihori, R. F. Olsson, M. Ramanathan, T. E. Rodriguez, A. A. Saad, B. N. Savani, G. J. Schiller, H. C. Schouten, J. R. Schriber, E. Scott, S. Seo, M. Sharma, S. Ganguly, E. A. Stadtmauer, J. Tay, L. B. To, D. H. Vesole, D. T. Vogl, J. L. Wagner, B. Wirk, W. A. Wood and A. D'Souza. "Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation." Bone Marrow Transplant 50: 1513-1518. (2015)

Vu, T., R. Austin, C. Paine Kuhn, C. Bruedigam, A. Song, S. Guignes, S. Jacquelin, H. S. Ramshaw, G. R. Hill, A. F. Lopez and S. W. Lane. "Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling." Haematologica (2015)

Weber, N., P. Mollee, B. Augustson, R. Brown, L. Catley, J. Gibson, S. Harrison, P. J. Ho, N. Horvath, W. Jaksic, D. Joshua, H. Quach, A. W. Roberts, A. Spencer, J. Szer, D. Talaulikar, B. To, A. Zannettino and H. M. Prince. "Management of systemic AL amyloidosis: recommendations of the Myeloma Foundation of Australia Medical and Scientific Advisory Group." Intern Med J 45: 371-382. (2015)

Wilson, C. H., S. Shalini, A. Filipovska, T. R. Richman, S. Davies, S. D. Martin, S. L. McGee, J. Puccini, A. Nikolic, L. Dorstyn and S. Kumar. "Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice." Cell Death Dis 6: e1597. (2015)

Wiszniak, S., F. E. Mackenzie, P. Anderson, S. Kabbara, C. Ruhrberg and Q. Schwarz. "Neural crest cell-derived VEGF promotes embryonic jaw extension." Proc Natl Acad Sci U S A 112: 6086-6091. (2015)

Wiszniak, S., M. Scherer, H. Ramshaw and Q. Schwarz. "Neuropilin-2 genomic elements drive cre recombinase expression in primitive blood, vascular and neuronal lineages." Genesis 53: 709-717. (2015)

Woodcock, J. M., C. Coolen, K. L. Goodwin, D. J. Baek, R. Bittman, M. S. Samuel, S. M. Pitson and A. F. Lopez. "Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics." Oncotarget 6: 14522-14536. (2015)

Xu, T., S. Nicolson, D. Denton and S. Kumar. "Distinct requirements of Autophagy-related genes in programmed cell death." Cell Death Differ 22: 1792-1802. (2015)

Xu, X., E. J. Jaehne, Z. Greenberg, P. McCarthy, E. Saleh, C. L. Parish, D. Camera, J. Heng, M. Haas, B. T. Baune, U. Ratnayake, M. van den Buuse, A. F. Lopez, H. S. Ramshaw and Q. Schwarz. "14-3-3zeta deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders." Sci Rep 5: 12434. (2015)

Yamamoto, T., K. Shimojima, N. Sangu, Y. Komoike, A. Ishii, S. Abe, S. Yamashita, K. Imai, T. Kubota, T. Fukasawa, T. Okanishi, H. Enoki, T. Tanabe, A. Saito, T. Furukawa, T. Shimizu, C. J. Milligan, S. Petrou, S. E. Heron, L. M. Dibbens, S. Hirose and A. Okumura. "Single nucleotide variations in CLCN6 identified in patients with benign partial epilepsies in infancy and/or febrile seizures." PLoS One 10: e0118946. (2015)

Yeung, D. T., D. J. Moulton, S. L. Heatley, E. Nievergall, P. Dang, J. Braley, S. Branford, S. Moore, C. G. Mullighan, T. P. Hughes and D. L. White. "Relapse of BCR-ABL1-like ALL mediated by the ABL1 kinase domain mutation T315I following initial response to dasatinib treatment." Leukemia 29: 230-232. (2015)

Yeung, D. T., M. P. Osborn, D. L. White, S. Branford, J. Braley, A. Herschtal, M. Kornhauser, S. Issa, D. K. Hiwase, M. Hertzberg, A. P. Schwarer, R. Filshie, C. K. Arthur, Y. L. Kwan, J. Trotman, C. J. Forsyth, J. Taper, D. M. Ross, J. Beresford, C. Tam, A. K. Mills, A. P. Grigg, T. P. Hughes, L. Australasian and G. Lymphoma. "TIDEL-II: first-line use of imatinib in CML with early switch to nilotinib for failure to achieve time-dependent molecular targets." Blood 125: 915-923. (2015)

Yeung, D. T., C. Tang, L. Vidovic, D. L. White, S. Branford, T. P. Hughes and A. S. Yong. "KIR2DL5B genotype predicts outcomes in CML patients treated with response-directed sequential imatinib/nilotinib strategy." Blood 126: 2720-2723. (2015)

Young, J. P., T. J. Price, J. Moore and A. R. Ruszkiewicz. "Human intestinal spirochetosis and its relationship to sessile serrated adenomas in an Australian population." Pathol Res Pract (2015)

Yu, F., C. P. Bracken, K. A. Pillman, D. M. Lawrence, G. J. Goodall, D. F. Callen and P. M. Neilsen. "p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA." PLoS One 10: e0129190. (2015)

Yu, M., P. Li, S. K. Basnet, M. Kumarasiri, S. Diab, T. Teo, H. Albrecht and S. Wang. "Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation." Eur J Med Chem 95: 116-126. (2015)

 

2014

Ahmed, F., N. K. Dutta, A. Zannettino, K. Vandyke and N. R. Choudhury. "Engineering interaction between bone marrow derived endothelial cells and electrospun surfaces for artificial vascular graft applications." Biomacromolecules 15: 1276-1287. (2014)

Ahmed, F., N. Roy Choudhury, N. K. Dutta, L. Zou and A. Zannettino. "Fabrication and characterisation of an electrospun tubular 3D scaffold platform of poly(vinylidene fluoride-co-hexafluoropropylene) for small-diameter blood vessel application." J Biomater Sci Polym Ed 25: 2023-2041. (2014)

Al-Ejeh, F., M. Pajic, W. Shi, M. Kalimutho, M. Miranda, A. M. Nagrial, A. Chou, A. V. Biankin, S. M. Grimmond, I. Australian Pancreatic Cancer Genome, M. P. Brown and K. K. Khanna. "Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma." Clin Cancer Res 20: 3187-3197. (2014)

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Ruzehaji, N., Z. Kopecki, E. Melville, S. L. Appleby, C. S. Bonder, R. M. Arkell, R. Fitridge and A. J. Cowin. "Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes." Diabetologia 57: 402-412. (2014)

Sabloff, M., R. M. Sobecks, K. W. Ahn, X. Zhu, M. de Lima, J. R. Brown, Y. Inamoto, H. K. Holland, M. D. Aljurf, M. J. Laughlin, R. T. Kamble, J. W. Hsu, B. M. Wirk, M. Seftel, I. D. Lewis, M. Arora, E. P. Alyea, M. E. Kalaycio, J. Cortes, R. T. Maziarz, R. P. Gale and W. Saber. "Does total body irradiation conditioning improve outcomes of myeloablative human leukocyte antigen-identical sibling transplantations for chronic lymphocytic leukemia?" Biol Blood Marrow Transplant 20: 421-424. (2014)

Sadras, T., M. Perugini, C. H. Kok, D. G. Iarossi, S. L. Heatley, G. Brumatti, M. S. Samuel, L. B. To, I. D. Lewis, A. F. Lopez, P. G. Ekert, H. S. Ramshaw and R. J. D'Andrea. "Interleukin-3-mediated regulation of beta-catenin in myeloid transformation and acute myeloid leukemia." J Leukoc Biol 96: 83-91. (2014)

Salmanidis, M., K. Pillman, G. Goodall and C. Bracken. "Direct transcriptional regulation by nuclear microRNAs." Int J Biochem Cell Biol 54: 304-311. (2014)

Sandow, J. J., L. Dorstyn, L. A. O'Reilly, M. Tailler, S. Kumar, A. Strasser and P. G. Ekert. "ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis." Cell Death Differ 21: 475-480. (2014)

Scheffner, M. and S. Kumar. "Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects." Biochim Biophys Acta 1843: 61-74. (2014)

Shahnam, A., D. M. Roder, E. A. Tracey, S. J. Neuhaus, M. P. Brown and M. J. Sorich. "Can cancer registries show whether treatment is contributing to survival increases for melanoma of the skin at a population level?" J Eval Clin Pract 20: 74-80. (2014)

Shalini, S., J. Puccini, C. H. Wilson, J. Finnie, L. Dorstyn and S. Kumar. "Caspase-2 protects against oxidative stress in vivo." Oncogene (2014)

Smith, E., A. R. Ruszkiewicz, G. G. Jamieson and P. A. Drew. "IGFBP7 is associated with poor prognosis in oesophageal adenocarcinoma and is regulated by promoter DNA methylation." Br J Cancer 110: 775-782. (2014)

Sobecks, R. M., J. F. Leis, R. P. Gale, K. W. Ahn, X. Zhu, M. Sabloff, M. de Lima, J. R. Brown, Y. Inamoto, G. A. Hale, M. D. Aljurf, R. T. Kamble, J. W. Hsu, S. Z. Pavletic, B. Wirk, M. D. Seftel, I. D. Lewis, E. P. Alyea, J. Cortes, M. E. Kalaycio, R. T. Maziarz and W. Saber. "Outcomes of human leukocyte antigen-matched sibling donor hematopoietic cell transplantation in chronic lymphocytic leukemia: myeloablative versus reduced-intensity conditioning regimens." Biol Blood Marrow Transplant 20: 1390-1398. (2014)

Soverini, S., S. Branford, F. E. Nicolini, M. Talpaz, M. W. Deininger, G. Martinelli, M. C. Muller, J. P. Radich and N. P. Shah. "Implications of BCR-ABL1 kinase domain-mediated resistance in chronic myeloid leukemia." Leuk Res 38: 10-20. (2014)

Staudacher, A. H., F. Al-Ejeh, C. K. Fraser, J. M. Darby, D. M. Roder, A. Ruszkiewicz, J. Manavis and M. P. Brown. "The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB(R)." EJNMMI Res 4: 2. (2014)

Staudacher, A. H., E. Bezak, A. Borysenko and M. P. Brown. "Targeted alpha-therapy using 227Th-APOMAB and cross-fire antitumour effects: preliminary in-vivo evaluation." Nucl Med Commun 35: 1284-1290. (2014)

Tan, B., M. Anaka, S. Deb, C. Freyer, L. M. Ebert, A. C. Chueh, S. Al-Obaidi, A. Behren, A. Jayachandran, J. Cebon, W. Chen and J. M. Mariadason. "FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis." Oncotarget 5: 264-276. (2014)

Tan, P., A. Wei, S. Mithraprabhu, N. Cummings, H. B. Liu, M. Perugini, K. Reed, S. Avery, S. Patil, P. Walker, P. Mollee, A. Grigg, R. D'Andrea, A. Dear and A. Spencer. "Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome." Blood Cancer J 4: e170. (2014)

Tillo, M., Q. Schwarz and C. Ruhrberg. "Mouse hindbrain ex vivo culture to study facial branchiomotor neuron migration." J Vis Exp (2014)

Toyo-oka, K., T. Wachi, R. F. Hunt, S. C. Baraban, S. Taya, H. Ramshaw, K. Kaibuchi, Q. P. Schwarz, A. F. Lopez and A. Wynshaw-Boris. "14-3-3epsilon and zeta regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain." J Neurosci 34: 12168-12181. (2014)

Wallington-Beddoe, C. T., J. A. Powell, D. Tong, S. M. Pitson, K. F. Bradstock and L. J. Bendall. "Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression." Cancer Res 74: 2803-2815. (2014)

Walsby, E., G. Pratt, H. Shao, A. Y. Abbas, P. M. Fischer, T. D. Bradshaw, P. Brennan, C. Fegan, S. Wang and C. Pepper. "A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine." Oncotarget 5: 375-385. (2014)

Yamane, D., D. R. McGivern, E. Wauthier, M. Yi, V. J. Madden, C. Welsch, I. Antes, Y. Wen, P. E. Chugh, C. E. McGee, D. G. Widman, I. Misumi, S. Bandyopadhyay, S. Kim, T. Shimakami, T. Oikawa, J. K. Whitmire, M. T. Heise, D. P. Dittmer, C. C. Kao, S. M. Pitson, A. H. Merrill, Jr., L. M. Reid and S. M. Lemon. "Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation." Nat Med 20: 927-935. (2014)

Yip, K. H., N. Kolesnikoff, C. Yu, N. Hauschild, H. Taing, L. Biggs, D. Goltzman, P. A. Gregory, P. H. Anderson, M. S. Samuel, S. J. Galli, A. F. Lopez and M. A. Grimbaldeston. "Mechanisms of vitamin D(3) metabolite repression of IgE-dependent mast cell activation." J Allergy Clin Immunol 133: 1356-1364, 1364 e1351-1314. (2014)

Zafar, A., F. Wu, K. Hardy, J. Li, W. J. Tu, R. McCuaig, J. Harris, K. K. Khanna, J. Attema, P. A. Gregory, G. J. Goodall, K. Harrington, J. E. Dahlstrom, T. Boulding, R. Madden, A. Tan, P. J. Milburn and S. Rao. "Chromatinized protein kinase C-theta directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells." Mol Cell Biol 34: 2961-2980. (2014)

Zhang, J., T. D. Le, L. Liu, B. Liu, J. He, G. J. Goodall and J. Li. "Identifying direct miRNA-mRNA causal regulatory relationships in heterogeneous data." J Biomed Inform 52: 438-447. (2014)

Zhang, J., T. D. Le, L. Liu, B. Liu, J. He, G. J. Goodall and J. Li. "Inferring condition-specific miRNA activity from matched miRNA and mRNA expression data." Bioinformatics 30: 3070-3077. (2014)

Zinonos, I., A. Labrinidis, V. Liapis, S. Hay, V. Panagopoulos, M. Denichilo, V. Ponomarev, W. Ingman, G. J. Atkins, D. M. Findlay, A. C. Zannettino and A. Evdokiou. "Doxorubicin overcomes resistance to drozitumab by antagonizing Inhibitor of Apoptosis Proteins (IAPs)." Anticancer Res 34: 7007-7020. (2014)

Zinonos, I., K. W. Luo, A. Labrinidis, V. Liapis, S. Hay, V. Panagopoulos, M. Denichilo, C. H. Ko, G. G. Yue, C. B. Lau, W. Ingman, V. Ponomarev, G. J. Atkins, D. M. Findlay, A. C. Zannettino and A. Evdokiou. "Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer." Int J Oncol 45: 532-540. (2014)

 

2013

Al-Ejeh F, Shi W, Miranda M , Simpson PT, Vargas AC, Song S, Wiegmans AP, Swarbrick A, Welm AL, Brown MP, Chenevix-Trench G, Lakhani SR, Khanna KK. Treatment of triple negative breast cancer using anti-EGFR directed radioimmunotherapy combined with radio-sensitizing chemotherapy and PARP inhibitor. J Nucl Med 54: 913-921, 2013.

Aloia AL, Duffy L, Pak V, Lee KE, Sanchez-Martinez S, Derse D, Heidecker G, Cornetta K, Rein A. A reporter system for replication-competent gammaretroviruses: the inGLuc-MLV-DERSE assay. Gene Therapy 20(2): 169-76, 2013.

Angelini S, Soverini S, Ravegnini G, Barnett M, Turrini E, Thornquist M, Pane F, Hughes TP, White DL, Radich J, Kim DW, Saglio G, Cilloni D, Iacobucci I, Perini G, Woodman R, Cantelli-Forti G, Baccarani M, Hrelia P, Martinelli G. Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy. Haematologica 98(2):193-200, 2013.

Attema JL, Bert AG, Lim YY, Kolesnikoff N, Lawrence DM, Pillman KA, Smith E, Drew PA, Khew-Goodall Y, Shannon MF, Goodall GJ. Identification of an enhancer that controls miR-200b~200a~429 gene expression in breast cancer cells. PlosOne 8, e75517, 2013.

Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF, Cervantes F, Clark RE, Cortes JE, Guilhot F, Hjorth-Hansen H, Hughes TP, Kantarjian HM, Kim DW, Larson RA, Lipton JH, Mahon FX, Martinelli G, Mayer J, Müller MC, Niederwieser D, Pane F, Radich JP, Rousselot P, Saglio G, Saußele S, Schiffer C, Silver R, Simonsson B, Steegmann JL, Goldman JM, Hehlmann R. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 122(6): 872-884, 2013.

Bachanova V, Marks DI, Zhang MJ, Wang H, de Lima M, Aljurf MD, Arellano M, Artz AS, Bacher U, Cahn JY, Chen YB, Copelan EA, Drobyski WR, Gale RP, Greer JP, Gupta V, Hale GA, Kebriaei P, Lazarus HM, Lewis ID, Lewis VA, Liesveld JL, Litzow MR, Loren AW, Miller AM, Norkin M, Oran B, Pidala J, Rowe JM, Savani BN, Saber W, Vij R, Waller EK, Wiernik PH, Weisdorf DJ. Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: impact of tyrosine kinase inhibitor and minimal residual disease. Leukemia Aug 30, Epub ahead of print, 2013

Bonder CS, Ebert LM. Fos-icking for control of angiogenesis: increasing the longevity of peritoneal dialysis. Kidney International, 84(6):1065-7, 2013.

Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL and François M. Control of retinoid levels by Cyp26b1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. Epub ahead of print, 2013.

Branford S, Yeung DT, Ross D, Prime J, Field C, Altamura H, Yeoman A, Georgievski J, Jamison BA, Phillis S, Sullivan B, Briggs NE, Hertzberg M, Seymour JF, Reynolds J, Hughes T. Early molecular response and female sex strongly predict achievement of stable undetectable BCR-ABL1, a criterion for imatinib discontinuation in patients with CML. Blood 121:3818-24, 2013

Brown MP, Burdett N. Targeted therapies, aspects of pharmaceutical and oncological management. Cancer Forum 37: 70-80, 2013

Brumatti G, Salmanidis M, Kok CH, Bilardi RA, Sandow JJ, Silke N, Mason K, Visser J, Jabbour AM, Glaser SP, Okamoto T, Bouillet P, D'Andrea RJ, Ekert PG. HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia. Oncotarget 4(11):1933-47, 2013

Carella AM, Branford S, Deininger M, Mahon FX, Saglio G, Eiring A, Khorashad J, O’Hare T and Goldman J. What challenges remain in CML research? Haematologica 98:1168-1172, 2013

Carr JM, Kua T, Clarke JN, Calvert JK, Zebol JR, Beard MR, Pitson SM. Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA. J Gen Virol. 94(Pt 11):2437-48. 2013

Cortes JE, Kim DW, Pinilla-Ibarz J, le Coutre P, Paquette R, Chuah C, Nicolini FE, Apperley JF, Khoury HJ, Talpaz M, DiPersio J, DeAngelo DJ, Abruzzese E, Rea D, Baccarani M, Müller MC, Gambacorti-Passerini C, Wong S, Lustgarten S, Rivera VM, Clackson T, Turner CD, Haluska FG, Guilhot F, Deininger MW, Hochhaus A, Hughes T, Goldman JM, Shah NP, Kantarjian H; PACE Investigators. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med. 369(19):1783-1796, 2013.

Denton D, Aung-Htut M, Lorensuhewa N, Nicolson S, Zhu W, Mills K, Cakouros D, Bergmann A, Kumar S. UTX coordinates steroid hormone mediated autophagy and cell death. Nature Communications 4: 2916, 2013.

Denton D, Aung-Htut M, Kumar S. Developmentally programmed cell death in Drosophila. BBA- Molecular Cell Research 1833: 3499-3506, 2013

Diakiw SM, D'Andrea RJ, Brown AL. The double life of KLF5: opposing roles in regulation of gene-expression, cellular function, and transformation. IUBMB Life 65(12):999-1011, 2013.

Diakiw SM, Perugini M, Kok CH, Engler GA, Cummings N, To LB, Wei AH, Lewis ID, Brown AL, D'Andrea RJ. Methylation of KLF5 contributes to reduced expression in AML and is associated with poor overall survival, British Journal of Haematology 161(6):884-8, 2013.

Dimasi D, Sun WY and Bonder CS. Neutrophil interactions with the vascular endothelium. International Immunopharmacology, S1567-5769(13)00280-4, 2013.

Dorstyn L, Kumar S. Insect Caspases. In: Handbook of Proteolytic Enzymes (Third Edition) (Rawlings ND & Salvesen G eds). ISBN: 978-0-12-382219-2. Elsevier, Oxford, UK. Chapter 514: 2286-2295, 2013.

Eadie LN, Hughes TP, White DL. Interaction of the Efflux Transporters ABCB1 and ABCG2 With Imatinib, Nilotinib, and Dasatinib. Clin Pharmacol Ther. 2013 Oct 9. [Epub ahead of print]

Eadie LN, Saunders VA, Hughes TP, White DL. Degree of kinase inhibition achieved in vitro by imatinib and nilotinib is decreased by high levels of ABCB1 but not ABCG2. Leuk Lymphoma. 2013 Mar; 54(3): 569-578.

Eberhardt WE, Mitchell P, Schiller JH, Brown MP, Thomas M, Mills G, Jehl V, Urva SR, DeLeo JJ, Anak O, Papadimitrakopoulou V. Feasibility of Adding Everolimus to Carboplatin and Paclitaxel, With or Without Bevacizumab, for Treatment-Naive, Advanced Non–Small Cell Lung Cancer. Invest New Drugs 1-12, 2013 DOI: 10.1007/s10637-013-9958-3.

Ekberg, JA, Boase NA, Rychkov, G, Manning J, Poronnik P, Kumar S. Nedd4-2 (NEDD4L) controls intracellular Na(+)-mediated activity of voltage-gated sodium channels in primary cortical neurons. Biochem. J. 457 (doi:10.1042/BJ20131275), 2013.

Gallipoli P, Stobo J, Heaney N, Nicolini FE, Clark R, Wilson G, Tighe J, McLintock L, Hughes T, Michor F, Paul J, Drummond M, Holyoake TL. Safety and efficacy of pulsed imatinib with or without G-CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up. Br J Haematol. 163(5): 674-676, 2013.


Giles KM, Kalinowski FC, Candy PA, Epis MR, Zhang PM, Redfern A, Stuart L, Goodall GJ, Leedman PJ. Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib. Mol Cancer Therapeutics 12, 2541–58, 2013.

Giles FJ, le Coutre PD, Pinilla-Ibarz J, Larson RA, Gattermann N, Ottmann OG, Hochhaus A, Radich JP, Saglio G, Hughes TP, Martinelli G, Kim DW, Novick S, Gillis K, Fan X, Cortes J, Baccarani M, Kantarjian HM. Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study. Leukemia. 27(1): 107-112, 2013.

Grinfeld J, Gerrard G, Alikian M, Alonso-Dominguez J, Ale S, Valgañon M, Nteliopoulos G, White D, Marin D, Hedgley C, O'Brien S, Clark R, Goldman JM, Milojkovic D, Apperley JF, Foroni L. A common novel splice variant of SLC22A1 (OCT1) is associated with impaired responses to imatinib in patients with chronic myeloid leukaemia. Br J Haematol. 163(5): 631-639, 2013.

Helbig KJ, Beard MR. The Role of Viperin in the Innate Antiviral Response. J Mol Biol. Oct 22. (13)00664-5. 2013.

Helbig KJ, Carr JM, Calvert JK, Wati S, Clarke JN, Eyre NS, Narayana SK, Fiches GN, McCartney EM, Beard MR. Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin. PLoS Negl Trop Dis. 2013.

Hercus TR, Dhagat U, Kan WL, Broughton SE, Nero TL, Perugini M, Sandow JJ, D'Andrea RJ, Ekert PG, Hughes T, Parker MW, Lopez AF. Signalling by the βc family of cytokines. Cytokine & Growth Factor Reviews 24(3):189-201, 2013.

Hiwase DK, Saunders VA, Nievergall E, Ross DD, White DL, Hughes TP. Dasatinib targets chronic myeloid leukemia-CD34+ progenitors as effectively as it targets mature cells. Haematologica. 98(6): 896-900, 2013.

Hochhaus A, Saglio G, Larson RA, Kim DW, Etienne G, Rosti G, De Souza C, Kurokawa M, Kalaycio ME, Hoenekopp A, Fan X, Shou Y, Kantarjian HM, Hughes TP. Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Blood. 121(18): 3703-3708, 2013.

Hochhaus A, Saglio G, Larson RA, Kim DW, Etienne G, Rosti G, De Souza C, Kurokawa M, Kalaycio ME, Hoenekopp A, Fan X, Shou Y, Kantarjian HM, Hughes TP, White HE, Hedges J, Bendit I, Branford S, Colomer D, Hughes T, Kamel-Reid S, Kim DW, Modur V, Müller MC, Pagnano KB, Pane F, Radich J, Cross NC, Labourier E. Establishment and validation of analytical reference panels for the standardization of quantitative BCR-ABL1 measurements on the international scale. Clin Chem. 59(6): 938-948, 2013.

Holmfeldt L, Wei L, Diaz-Flores E, Walsh M, Zhang J, Ding L, Payne-Turner D, Churchman M, Andersson A, Chen SC, McCastlain K, Becksfort J, Ma J, Wu G, Patel SN, Heatley SL, Phillips LA, Song G, Easton J, Parker M, Chen X, Rusch M, Boggs K, Vadodaria B, Hedlund E, Drenberg C, Baker S, Pei D, Cheng C, Huether R, Lu C, Fulton RS, Fulton LL, Tabib Y, Dooling DJ, Ochoa K, Minden M, Lewis ID, To LB, Marlton P, Roberts AW, Raca G, Stock W, Neale G, Drexler HG, Dickins RA, Ellison DW, Shurtleff SA, Pui CH, Ribeiro RC, Devidas M, Carroll AJ, Heerema NA, Wood B, Borowitz MJ, Gastier-Foster JM, Raimondi SC, Mardis ER, Wilson RK, Downing JR, Hunger SP, Loh ML, Mullighan CG. The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nature Genetics 45(3):242-52, 2013.

Hughes TP and White CL. “Which TKI? An embarrassment of riches for CML patients…” ASH Education Book. American Society of Haematology. New Orleans.1:168-175, 2013.

Hughes TP, Saglio G, Kantarjian HM, Guilhot F, Niederwieser D, Rosti G, Nakaseko C, De Souza CA, Kalaycio ME, Meier S, Fan X, Menssen HD, Larson RA, Hochhaus A. Early molecular response predicts outcomes in patients with chronic myeloid leukemia in chronic phase treated with frontline nilotinib or imatinib. Blood. 2013 Dec 11.

Ibbetson SJ, Pyne NT, Pollard AN, Olson MF, Samuel MS. Mechanotransduction pathways promoting tumor progression are activated in invasive human squamous cell carcinoma.
Am J Pathol. 183(3): 930-93, 2013.

Jabbour EJ, Hughes TP, Cortés JE, Kantarjian HM, Hochhaus A. Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia. Leuk Lymphoma. 2013 Nov 12. [Epub ahead of print]

Jabbour E, le Coutre PD, Cortes J, Giles F, Bhalla KN, Pinilla-Ibarz J, Larson RA, Gattermann N, Ottmann OG, Hochhaus A, Hughes TP, Saglio G, Radich JP, Kim DW, Martinelli G, Reynolds J, Woodman RC, Baccarani M, Kantarjian HM. Prediction of outcomes in patients with Ph+ chronic myeloid leukemia in chronic phase treated with nilotinib after imatinib resistance/intolerance. Leukemia. 2013 Apr;27(4): 907-913.

Kartopawiro J, Bower NI, Karnezis T, Kazenwadel J, Betterman KL, Lesieur E, Koltowska K, Astin J, Crosier P, Vermeren S, Achen MG, Stacker SA, Smith KA, Harvey NL, François M and Hogan BM. Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Hum Mol Genet. Epub ahead of print, 2013.

Kok CH, Brown AL, Perugini M, Iarossi DG, Lewis ID, D'Andrea RJ. The preferential occurrence of FLT3-TKD mutations in inv(16) AML and impact on survival outcome: a combined analysis of 1053 core-binding factor AML patients. British Journal of Haematology 160(4):557-9, 2013.

Kok CH, Leclercq T, Watkins DB, Saunders V, Wang J, Hughes TP, White DL. Elevated PTPN2 expression is associated with inferior molecular response in de-novo chronic myeloid leukaemia patients. Leukemia. 2013 Nov 6. [Epub ahead of print].

Kok CH, Watkins DB, Leclercq T, D'Andrea RJ, Hughes TP, White DL. Low GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation. Leukemia 6:1427-30, 2013.

Koltowska K, Betterman KL, Harvey NL* and Hogan BM*. Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature. Development. 140:1857-70, 2013.
* Equal senior author

Khoury HJ, Talpaz M, DiPersio J, DeAngelo DJ, Abruzzese E, Rea D, Baccarani M, Müller MC, Gambacorti-Passerini C, Wong S, Lustgarten S, Rivera VM, Clackson T, Turner CD, Haluska FG, Guilhot F, Deininger MW, Hochhaus A, Hughes T, Goldman JM, Shah NP, Kantarjian H; PACE Investigators. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med. 369(19):1783-1796, 2013.

Le TD, Liu L, Tsykin A, Goodall GJ, Liu B, Sun B_Y, and Li J. Inferring microRNA-mRNA causal regulatory relationships from expression data. Bioinformatics 29:765-771, 2013.

Lees JG, Ching YW, Adams DH, Bach CT, Samuel MS, Kee AJ, Hardeman EC, Gunning P, Cowin AJ, O'Neill GM. Tropomyosin regulates cell migration during skin wound healing.
J Invest Dermatol. 133(5): 1330-1339, 2013.

Limaye V, Bonder CS, Sun WY, Lester S, Roberts-Thomson, Blumbergs P. Levels of soluble adhesion molecules and their associations in inflammatory myositis. International Journal of Rheumatic Diseases, 16(1):99-101, 2013.

Li S, Garrett-Bakelman FE, Akalin A, Zumbo P, Levine R, To LB, Lewis ID, Brown AL, D'Andrea RJ, Melnick A, Mason CE. An optimized algorithm for detecting and annotating regional differential methylation. BMC Bioinformatics 14(5):S10, 2013.

Li X, Roslan S, Johnstone CN, Wright JA, Bracken CP, Anderson M, Bert AG,Selth LA, Anderson RA, Goodall GJ, Gregory PA, Khew-Goodall Y. MiR-200 can repress breast cancer metastasis through ZEB1-independent, but moesin-dependent pathways. Oncogene Accepted 26 July 2013.

Lim YY, Wright JA, Attema JA, Gregory PA, Bert AG, Smith E, Thomas D, Lopez AF, Drew PA, Khew-Goodall Y and Goodall GJ. Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state. J. Cell Sci. 126:2256-2266, 2013.

Liu B, Liu L, A Tsykin, GJ Goodall, MJ Cairns, and J Li. Discovering Functional microRNA-mRNA Regulatory Modules in Heterogeneous Data. In MicroRNA Cancer Regulation. Advanced Concepts, Bioinformatics and Systems Biology Tools, Advances in Experimental Medicine and Biology, Vol. 774, Schmitz, Ulf; Wolkenhauer, Olaf; Vera, Julio (Eds.), pp. 267-290 (Chapter 14), Springer, 2013.

Liu PY, Xu N, Malyukova A, Scarlett CJ, Sun YT, Zhang XD, Ling D, Su S-P, Nelson C, Chang DK, Koach J, Tee AE, Haber M, Norris MD, Toon C, Rooman I, Xue C, Cheung BB, Kumar S, Marshall GM, Biankin AV, Liu T. The histone deacetylase SIRT2 stabilizes Myc oncoproteins. Cell Death Differ. 20: 503-514, 2013.

McCartney EM, Helbig KJ, Narayana SK, Eyre NS, Aloia AL, Beard MR. Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus. Hepatology. 58(5):1558-68. 2013.

Mellor JD, Brown MP, Irving HR, Zalcberg JR, Dobrovic A. Are Fc gamma receptor polymorphisms predictive of the response to monoclonal antibodies in cancer. J Haematol Oncol 6: 1, 2013.

Molina L, Fasquelle L, Nouvian Rg, Salvetat N, Scott HS, Guipponi M, Molina F, Puel J-L, Delprat B. Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Human Molecular Genetics 22:1289-1299, 2013.

Moriconi F, Beard MR, Yuen LK. Bioinformatics methods for the analysis of hepatitis viruses. Antivir Ther ;18531-9. 2013.

Nathanson KL, Martin A-M, Wubbenhorst B, Greshock J, Letrero T, D’Andrea K, O’Day S, Infante JR, Falchook GS, Arkenau T, Millward M, Brown MP, Pavlick A, Davies M, Ma B, Gagnon R, Curtis M, Lebowitz P, Kefford R, Long GV. Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor Dabrafenib (GSK2118436). Clin Cancer Res 19: 4868-4878, 2013.

Neilsen PM, Noll JE, Mattiske S, Bracken CP, Gregory PA, Schulz RB, Lim SP, Kumar R, Suetani RJ, Goodall GJ and Callen DF. Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogene 32:2992-3000, 2013.

Ng RL, Scott NM, Strickland DH, Gorman S, Grimbaldeston MA, Norval M, Waithman J, Hart PH. Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice. J Immunol 190:5471-84, 2013.

Nievergall E, Ramshaw HS, Yong AS, Biondo M, Busfield SJ, Vairo G, Lopez AF, Hughes TP, White DL, Hiwase DK. Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells. Blood. 2013 Dec 20. [Epub ahead of print]

Paterson EL, Kazenwadel J, Bert AG, Khew-Goodall Y, Ruszkiewicz A, Goodall GJ Downregulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression. Neoplasia 15:180-191, 2013.

Parker WT, Yeoman AL, Jamison BA, Yeung DT, Scott HS, Hughes TP, Branford S. BCR-ABL1 kinase domain mutations may persist sub-clonally for many years and lead to subsequent TKI resistance. British Journal of Cancer 109:1593, 2013.

Paterson EL, Schnitzler M and Goodall GJ, MicroRNAs and the Progression of Colorectal Cancer, in Metastatic Cancer: Integrated Organ System and Biological Approach, Edited by: Rahul Jandial and Kent Hunter, Landes Biosciences. ISBN: 978-1-58706-659-7 In Press; Publication date: April 1, 2013 http://www.landesbioscience.com/curie/chapter/5342/

Penko D, Rojas-Canales D, Peiris H, Sun WY, Drogemuller C, Coates PTH, Bonder CS, Jessup CJ. Endothelial progenitor cells enhance islet engraftment, influence beta cell function and modulate connexin 36 expression. Cell Transplantation, in press.

Perugini M, Iarossi DG, Kok CH, Cummings N, Diakiw SM, Brown AL, Danner S, Bardy P, To LB, Wei AH, Lewis ID, D'Andrea RJ. GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations. Leukemia 27(7):1588-92, 2013.

Pham DH, Powell JA, Gliddon BL, Moretti PAB, Tsykin A, Van der Hoek M, Kenyon R, Goodall GJ and Pitson SM (2013) Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1. Oncogene, in press (accepted 21 October 2013).

Pishas KI, Neuhaus SJ, Clayer MT, Adwal A, Brown MP, Evdokiou A, Callen DF, Neilsen PM. Pre-activation of the p53 pathway through Nutlin-3a sensitises sarcomas to Drozitumab therapy. Oncology Reports 30: 471-477, 2013.

Puccini J, Dorstyn L, Kumar S. Caspase-2 as a tumour suppressor. Cell Death Differ. 20: 1133-1139, 2013.

Puccini J, Dorstyn L, Kumar S. Genetic background and tumour susceptibility in mouse models. Cell Death Differ. 20: 964, 2013.

Puccini J, Shalini S, Voss AK, Gatei M, Wilson CH, Hiwase DK, Lavin MF, Dorstyn L, Kumar S. Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proc Nat Acad Sci USA 110:19920-19925, 2013.

Roberts ND, Kortschak D, Parker WT, Schreiber AW, Branford S, Scott HS, Glonek G, Adelson DL. A comparative analysis of algorithms for somatic SNV detection in cancer. Bioinformatics 29:2223, 2013.

Roediger B, Kyle R, Yip KH, Sumaria N, Guy TV, Kim BS, Mitchell AJ, Tay SS, Jain R, Forbes-Blom E, Chen X, Tong PL, Bolton HA, Artis D, Paul WE, Fazekas de St Groth B, Grimbaldeston MA, Le Gros G, Weninger W. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol 14:564-73, 2013.

Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O. Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. J Clin Invest. 123: 657–665, 2013.

Ross DM, Branford S, Seymour JF, Schwarer AP, Arthur C, Yeung DT, Dang P, Goyne JM, Slader C, Filshie RJ, Mills AK, Melo JV, White DL, Grigg AP, Hughes TP. Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER Study. Blood 122:515, 2013.

Ross DM, O'Hely M, Bartley PA, Dang P, Score J, Goyne JM, Sobrinho-Simoes M, Cross NC, Melo JV, Speed TP, Hughes TP, Morley AA. Distribution of genomic breakpoints in chronic myeloid leukemia: analysis of 308 patients. Leukemia. 27(10): 2105-2107, 2013.

Roy SS, Gonugunta VK, Bandyopadhyay A, RaoMK, Goodall GJ, Sun LZ, Tekmal RR, Vadlamudi RK. Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer. Oncogene. Accepted 19 June 2013.

Salmanidis M, Brumatti G, Green BD, van den Bergen JA, Sandow JJ, Bert AG, Sladic R, Puthalakath H, Rohrbeck L, Okamoto T, Bouillet P, Herold MJ, Goodall GJ, Jabbour AM, Ekert PG. Hoxb8 regulates miR-17~92 to promote survival and proliferation. Cell Death and Differentiation 20, 1370–80, 2013.

Schafranek L, Leclercq TM, White DL, Hughes TP. Clarithromycin enhances dasatinib-induced cell death in chronic myeloid leukemia cells, by inhibition of late stage autophagy. Leuk Lymphoma. 54(1): 198-201, 2013.

Scott HS. Human "monogenic" disease gene discovery: when models of inheritance go wrong. Hum Mutat 34:v, 2013.

Selth LA, Townley SL, Bert AB, Stricker PD, Sutherland PD, Horvath LG, Goodall GJ, Butler LM, Tilley WD. Circulating microRNAs predict biochemical recurrence in prostate cancer patients. British Journal of Cancer. Accepted 22 June 2013.

Shah S, Schrader KA, Waanders E, Timms AE, Vijai J, Miething C, Wechsler J, Yang J, Hayes J, Klein RJ, Zhang J, Wei L, Wu G, Rusch M, Nagahawatte P, Ma J, Chen SC, Song G, Cheng J, Meyers P, Bhojwani D, Jhanwar S, Maslak P, Fleisher M, Littman J, Offit L, Rau-Murthy R, Fleischut MH, Corines M, Murali R, Gao X, Manschreck C, Kitzing T, Murty VV, Raimondi SC, Kuiper RP, Simons A, Schiffman JD, Onel K, Plon SE, Wheeler DA, Ritter D, Ziegler DS, Tucker K, Sutton R, Chenevix-Trench G, Li J, Huntsman DG, Hansford S, Senz J, Walsh T, Lee M, Hahn CN, Roberts KG, King MC, Lo SM, Levine RL, Viale A, Socci ND, Nathanson KL, Scott HS, Daly M, Lipkin SM, Lowe SW, Downing JR, Altshuler D, Sandlund JT, Horwitz MS, Mullighan CG, Offit K. A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nat Genet 45, 2013.

Stevens NE, Fraser CK, Alshrifi M, Brown MP, Diener KD, Hayball JD. An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccineTM is functionally superior to Freund's adjuvant. PLoS ONE 8: e68895, 2013

Soverini S, Branford S, Nicolini F, Talpaz M, Deininger M, Martinelli G, Müller M, Radich J, Shah N. Implications of BCR-ABL1 kinase domain-mediated resistance in chronic myeloid leukemia. Leukemia Research 38:10-20, 2013.

Stein A, Martinelli G, Hughes TP, Müller, Beppu L, Gottardi E, Branford S, Soverini S, Woodman R, Hochhaus A, Kim DW, Saglio G, Radich JP. Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia. BMC Cancer 13:173, 2013.

Tan DS, Gan PY, O'Sullivan KM, Hammett MV, Summers SA, Ooi JD, Lundgren BA, Boyd RL, Scott HS, Kitching AR, Chidgey AP, Holdsworth SR. Thymic Deletion and Regulatory T Cells Prevent Antimyeloperoxidase GN. J Am Soc Nephrol 24:573-585, 2013.

Tan P, Wei A, Mithraprabhu S, Cummings N, Liu HB, Perugini M, Reed K, Avery S, Patil S, Walker P, Mollee P, Grigg A, D'Andrea RJ, Dear A, and Spencer A. Dual Epigenetic Targeting with Panobinostat and Azacitidine in Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome. Blood Cancer Journal Epub ahead of print, 2013.

Thomas D, Powell JA, Green BD, Barry EF, Ma Y, Woodcock J, Fitter S, Zannettino AC, Pitson SM, Hughes TP, Lopez AF, Shepherd PR, Wei AH, Ekert PG, Guthridge MA. Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS Biol 11(3), 2013.

Thomson DW, Bracken CP, Szubert JM, Goodall GJ. On measuring miRNAs after transient transfection of mimics or antisense inhibitors. PlosOne 8:e55214, 2013.

Watkins DB, Hughes TP, White DL, D'Andrea RJ. NPM1 mutations occur rarely or not at all in chronic myeloid leukaemia patients in chronic phase or blast crisis. Leukemia 27(2):489-90, 2013.

White HE, Hedges J, Bendit I, Branford S, Colomer D, Hochhaus A, Hughes T, Kamel-Reid S, Kim D-W, Modur V, Muller MC, Pagnano KB, Pane F, Radich J, Cross NCP, Labourier E. Establishment and Validation of Analytical Reference Panels for the Standardization of Quantitative BCR-ABL1 Measurements on the International Scale. Clinical Chemistry 59:938-948, 2013.

Wiszniak S, Kabbara S, Lumb R, Scherer M, Secker G, Harvey N, Kumar S, Schwarz Q. The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties. Developmental Biology 383: 186-200, 2013

Yip KH, Kolesnikoff N, Yu C, Hauschild N, Taing H, Biggs L, Goltzman D, Gregory PA, Anderson PH, Samuel MS, Galli SJ, Lopez AF, Grimbaldeston MA. Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation. J Allergy Clin Immunol (2013) in press.

Young JA, Ting KK, Li J, Moller T, Dunn L, Moses YJ, Prado-Lourenço L, Khachigian L, Ng M, Gregory PA, Goodall GJ, Tsykin A, Lichtenstein I, Hahn CN, Tran N, Shackel N, Kench J, McCaughan G, Vadas MA, Gamble JR. Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin restricted miRNA antagonists of miR-27. Blood Accepted 18 Aug 2013.

2012

Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JM. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest 122: 3170-3183, 2012

Aloia AL, Locarnini S, Beard MR. Antiviral resistance and direct-acting antiviral agents for HCV. Antivir Ther 17: 1147-1162, 2012

Appleby SL, Cockshell MP, Pippal JB, Thompson EJ, Barrett JM, Tooley K, Sen S, Sun WY, Grose R, Nicholson I, Levina V, Cooke I, Talbo G, Lopez AF, Bonder CS. Characterization of a distinct population of circulating human non-adherent endothelial forming cells and their recruitment via intercellular adhesion molecule-3. PLoS One 7: e46996, 2012

Balasubramanian P, Chendamarai E, Markose P, Fletcher L, Branford S, George B, Mathews V, Chandy M, Srivastava A. International reporting scale of BCR-ABL1 fusion transcript in chronic myeloid leukemia: first report from India. Acta Haematol 127: 135-142, 2012

Ballen KK, Woolfrey AE, Zhu X, Ahn KW, Wirk B, Arora M, George B, Savani BN, Bolwell B, Porter DL, Copelan E, Hale G, Schouten HC, Lewis I, et al. Allogeneic hematopoietic cell transplantation for advanced polycythemia vera and essential thrombocythemia. Biol Blood Marrow Transplant 18: 1446-1454, 2012

Bard-Chapeau EA, Jeyakani J, Kok CH, Muller J, Chua BQ, Gunaratne J, Batagov A, Jenjaroenpun P, Kuznetsov VA, Wei CL, D'Andrea RJ, Bourque G, Jenkins NA, Copeland NG. Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proc Natl Acad Sci U S A 109: 2168-2173, 2012

Beard MR. HCV Replication. Advanced Therapy for Hepatitis C. Geoffery W. Wiley-Blackwell. 2012

Betterman KL, Paquet-Fifield S, Asselin-Labat ML, Visvader JE, Butler LM, Stacker SA, Achen MG, Harvey NL. Remodelling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli. Am J Pathol 181: 2225-2238, 2012

Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491: 399-405, 2012

Bird RJ, Kenealy M, Forsyth C, Wellwood J, Leahy MF, Seymour JF, To LB. When should iron chelation therapy be considered in patients with myelodysplasia and other bone marrow failure syndromes with iron overload? Intern Med J 42: 450-455, 2012

Black CL, Foster-Smith E, Lewis ID, Faull RJ, Sidhu SK. Post-transplant plasmablastic lymphoma of the skin. Australas J Dermatol 2012

Blake SJ, Hughes TP, Lyons AB. Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A. Exp Hematol 40: 612-621 e616, 2012

Branford S. Continued therapeutic response monitoring in optimal responders with CML. Clin Adv Hematol Oncol 10: 819-821, 2012

Branford S. Monitoring after successful therapy for chronic myeloid leukemia. Hematology Am Soc Hematol Educ Program 2012: 105-110, 2012

Branford S, Kim DW, Soverini S, Haque A, Shou Y, Woodman RC, Kantarjian HM, Martinelli G, Radich JP, Saglio G, Hochhaus A, Hughes TP, Muller MC. Initial molecular response at 3 months may predict both response and event-free survival at 24 months in imatinib-resistant or -intolerant patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase treated with nilotinib. J Clin Oncol 30: 4323-4329, 2012

Branford S, Yeung DT, Prime JA, Choi SY, Bang JH, Park JE, Kim DW, Ross DM, Hughes TP. BCR-ABL1 doubling times more reliably assess the dynamics of CML relapse compared with the BCR-ABL1 fold rise: implications for monitoring and management. Blood 119: 4264-4271, 2012

Broughton SE, Dhagat U, Hercus TR, Nero TL, Grimbaldeston MA, Bonder CS, Lopez AF, Parker MW. The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunol Rev 250: 277-302, 2012

Broughton SE, Hercus TR, Lopez AF, Parker MW. Cytokine receptor activation at the cell surface. Curr Opin Struct Biol 22: 351-359, 2012

Brown AL, Salerno DG, Sadras T, Engler GA, Kok CH, Wilkinson CR, Samaraweera SE, Sadlon TJ, Perugini M, Lewis ID, Gonda TJ, D'Andrea RJ. The GM-CSF receptor utilizes beta-catenin and Tcf4 to specify macrophage lineage differentiation. Differentiation 83: 47-59, 2012

Bruce CR, Risis S, Babb JR, Yang C, Kowalski GM, Selathurai A, Lee-Young RS, Weir JM, Yoshioka K, Takuwa Y, Meikle PJ, Pitson SM, Febbraio MA. Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice. Diabetes 61: 3148-3155, 2012

Cakouros D, Isenmann S, Cooper L, Zannettino A, Anderson P, Glackin C, Gronthos S. Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A/Arf locus in mesenchymal stem cells. Mol Cell Biol 32: 1433-1441, 2012

Casolari DA, Makri M, Yoshida C, Muto A, Igarashi K, Melo JV. Transcriptional suppression of BACH2 by the Bcr-Abl oncoprotein is mediated by PAX5. Leukemia doi 10.1038/leu.2012.220, 2012

Castrechini NM, Murthi P, Qin S, Kusuma GD, Wilton L, Abumaree M, Gronthos S, Zannettino A, Gude NM, Brennecke SP, Kalionis B. Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua. Reprod Sci 19: 1302-1314, 2012

Chan W, McRae S, Selva D. Protein C deficiency with concurrent essential thrombocytosis and orbital compartment syndrome. Clin Exp Ophthal 40: 325-6, 2012

Cheah PS, Ramshaw HS, Thomas PQ, Toyo-Oka K, Xu X, Martin S, Coyle P, Guthridge MA, Stomski F, van den Buuse M, Wynshaw-Boris A, Lopez AF, Schwarz QP. Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3zeta deficiency. Mol Psychiatry 17: 451-466, 2012

Christie M, Jorissen RN, Mouradov D, Sakthianandeswaren A, Li S, Day F, Tsui C, Lipton L, Desai J, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, et al. Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/beta-catenin signalling thresholds for tumourigenesis. Oncogene 10.1038/onc.2012.486, 2012

Cortes J, Goldman JM, Hughes T. Current issues in chronic myeloid leukemia: monitoring, resistance, and functional cure. J Natl Compr Canc Netw 10: S1-S13, 2012

Crotti TN, Dharmapatni AA, Alias E, Zannettino AC, Smith MD, Haynes DR. The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Res Ther 14: R245, 2012

Debrincat MA, Josefsson EC, James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT. Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival. Blood 119: 5850-5858, 2012

Denton D, Chang TK, Nicolson S, Shravage B, Simin R, Baehrecke EH, Kumar S. Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ 19: 1299-1307, 2012

Denton D, Nicolson S, Kumar S. Cell death by autophagy: facts and apparent artefacts. Cell Death Differ 19: 87-95, 2012

Diakiw SM, Kok CH, To LB, Lewis ID, Brown AL, D'Andrea RJ. The granulocyte-associated transcription factor Kruppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia. Leuk Res 36: 110-116, 2012

Dorstyn L, Puccini J, Wilson CH, Shalini S, Nicola M, Moore S, Kumar S. Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death Differ 19: 1288-1298, 2012

Edmund T, Beard MR. Mechanisms of Action of Antiviral Drugs: The Interferons Advanced Therapy in Hepatitis C. Geoffery W. Wiley-Blakwell. 2012

Fitter S, Vandyke K, Gronthos S, Zannettino AC. Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion. J Mol Endocrinol 48: 229-240, 2012

Francois M, Short K, Secker GA, Combes A, Schwarz Q, Davidson TL, Smyth I, Hong YK, Harvey NL, Koopman P. Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Dev Biol 364: 89-98, 2012

Gagliardi L, Ling KH, Kok CH, Carolan J, Brautigan P, Kenyon R, D'Andrea RJ, Van der Hoek M, Hahn CN, Torpy DJ, Scott HS. Genome-wide gene expression profiling identifies overlap with malignant adrenocortical tumours and novel mechanisms of inefficient steroidogenesis in familial ACTH-independent macronodular adrenal hyperplasia. Endocr Relat Cancer 19: L19-23, 2012

Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 19: 107-120, 2012

Garrick MD, Zhao L, Roth JA, Jiang H, Feng J, Foot NJ, Dalton H, Kumar S, Garrick LM. Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation. Biometals 25: 787-793, 2012

Ghosh P, Moore R, Vernon-Roberts B, Goldschlager T, Pascoe D, Zannettino A, Gronthos S, Itescu S. Immunoselected STRO-3+ mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs. J Neurosurg Spine 16: 479-488, 2012

Gorman S, Scott NM, Tan DH, Weeden CE, Tuckey RC, Bisley JL, Grimbaldeston MA, Hart PH. Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice. PLoS One 7: e46006, 2012

Guilhot F, Hughes TP, Cortes J, Druker BJ, Baccarani M, Gathmann I, Hayes M, Granvil C, Wang Y. Plasma exposure of imatinib and its correlation with clinical response in the Tyrosine Kinase Inhibitor Optimization and Selectivity Trial. Haematologica 97: 731-738, 2012

Hanfstein B, Muller MC, Hehlmann R, Erben P, Lauseker M, Fabarius A, Schnittger S, Haferlach C, Gohring G, Proetel U, Kolb HJ, Krause SW, Hofmann WK, Schubert J, Einsele H, Dengler J, Hanel M, Falge C, Kanz L, Neubauer A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Branford S, Hughes TP, et al. Early molecular and cytogenetic response is predictive for long-term progression-free and overall survival in chronic myeloid leukemia (CML). Leukemia 26: 2096-2102, 2012

Harvey NL, Gordon EJ. Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis. Vasc Cell 4: 15, 2012

Helbig KJ, Beard MR. The interferon signaling pathway genes as biomarkers of hepatitis C virus disease progression and response to treatment. Biomark Med 6: 141-150, 2012

Hercus TR, Broughton SE, Ekert PG, Ramshaw HS, Perugini M, Grimbaldeston M, Woodcock JM, Thomas D, Pitson S, Hughes T, D'Andrea RJ, Parker MW, Lopez AF. The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors 30: 63-75, 2012

Hiwase DK, Saunders VA, Nievergall E, Ross DD, White DL, Hughes TP. Dasatinib targets chronic myeloid leukemia-CD34+ progenitors as effectively as it targets mature cells. Haematologica 10.3324/haematol. 2012.070268, 2012

Ho YY, Penno M, Perugini M, Lewis I, Hoffmann P. Evaluating the efficacy of subcellular fractionation of blast cells using live cell labeling and 2D DIGE. Methods Mol Biol 854: 319-332, 2012

Howitt J, Lackovic J, Low LH, Naguib A, Macintyre A, Goh CP, Callaway JK, Hammond V, Thomas T, Dixon M, Putz U, Silke J, Bartlett P, Yang B, Kumar S, Trotman LC, Tan SS. Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol 196: 29-36, 2012

Jabbour AM, Gordon L, Daunt CP, Green BD, Kok CH, D'Andrea R, Ekert PG. p53-Dependent transcriptional responses to interleukin-3 signaling. PLoS One 7: e31428, 2012

Jamieson T, Clarke M, Steele CW, Samuel MS, Neumann J, Jung A, Huels D, Olson MF, Das S, Nibbs RJ, Sansom OJ. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest 122: 3127-3144, 2012

Juarez JG, Harun N, Thien M, Welschinger R, Baraz R, Pena AD, Pitson SM, Rettig M, DiPersio JF, Bradstock KF, Bendall LJ. Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood 119: 707-716, 2012

Kazenwadel J, Secker GA, Betterman KL, Harvey NL. In vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGFR1 signalling in lymphangiogenesis. PLoS One 7: e40497, 2012

Kazenwadel J, Secker GA, Liu YJ, Rosenfeld JA, Wildin RS, Cuellar-Rodriguez J, Hsu AP, Dyack S, Fernandez CV, Chong CE, Babic M, Bardy PG, Shimamura A, Zhang MY, Walsh T, Holland SM, Hickstein DD, Horwitz MS, Hahn CN, Scott HS, Harvey NL. Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood 119: 1283-1291, 2012

Kearney BJ, To LB, Kearney DJ, Roder D, Luke CG, Lewis ID, Giri P. Outcomes of lymphoma in South Australia, 1977-2007. Med J Aust 196: 54-57, 2012

Khew-Goodall Y, Goodall GJ. A microRNA that limits metastatic colonisation and endothelial recruitment. EMBO J 31: 786-787, 2012

Khew-Goodall Y, Goodall GJ. Stromal miR-320 keeps an oncogenic secretome in check. Nat Cell Biol 14: 124-125, 2012

Kinsella SM, Harvey NL. A comparison of the pelvic angle applied using lateral table tilt or a pelvic wedge at elective caesarean section. Anaesthesia 67: 1327-1331, 2012

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544, 2012

Larson RA, Hochhaus A, Hughes TP, Clark RE, Etienne G, Kim DW, Flinn IW, Kurokawa M, Moiraghi B, Yu R, Blakesley RE, Gallagher NJ, Saglio G, Kantarjian HM. Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up. Leukemia 26: 2197-2203, 2012

Larson RA, Yin OQ, Hochhaus A, Saglio G, Clark RE, Nakamae H, Gallagher NJ, Demirhan E, Hughes TP, Kantarjian HM, le Coutre PD. Population pharmacokinetic and exposure-response analysis of nilotinib in patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase. Eur J Clin Pharmacol 68: 723-733, 2012

Leong DW, Komen JC, Hewitt CA, Arnaud E, McKenzie M, Phipson B, Bahlo M, Laskowski A, Kinkel SA, Davey GM, Heath WR, Voss AK, Zahedi RP, Pitt JJ, Chrast R, Sickmann A, Ryan MT, Smyth GK, Thorburn DR, Scott HS. Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene. J Biol Chem 287: 20652-20663, 2012

Lim KG, Tonelli F, Berdyshev E, Gorshkova I, Leclercq T, Pitson SM, Bittman R, Pyne S, Pyne NJ. Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. Int J Biochem Cell Biol 44: 1457-1464, 2012

Ling SC, Lau EK, Al-Shabeeb A, Nikolic A, Catalano A, Iland H, Horvath N, Ho PJ, Harrison S, Fleming S, Joshua DE, Allen JD. Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1. Haematologica 97: 64-72, 2012

Lipka DB, Wagner MC, Dziadosz M, Schnoder T, Heidel F, Schemionek M, Melo JV, Kindler T, Muller-Tidow C, Koschmieder S, Fischer T. Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells. PLoS One 7: e40853, 2012

Macsai CE, Georgiou KR, Foster BK, Zannettino AC, Xian CJ. Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair. Bone 50: 1081-1091, 2012

Markey KA, Koyama M, Kuns RD, Lineburg KE, Wilson YA, Olver SD, Raffelt NC, Don ALJ
Varelias A, Robb RJ, Cheong M, Engwerda CR, Steptoe R J, Ramshaw HS, Lopez AF, Vega-Ramos J, Lew AM, Villadangos JA, Hill GR, Macdonald KPA. Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets. Blood 119: 5918-5930, 2012

Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C. NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Dev Biol 369: 277-285, 2012

McInnes N, Sadlon TJ, Brown CY, Pederson S, Beyer M, Schultze JL, McColl S, Goodall GJ, Barry SC. FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene 31: 1045-1054, 2012

McLintock C, Brighton T, Chunilal S, Dekker G, McDonnell N, McRae S, Muller P, Tran H, Walters BN, Young L. Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period. Aust N Z J Obstet Gynaecol 52: 14-22, 2012

McLintock C, Brighton T, Chunilal S, Dekker G, McDonnell N, McRae S, Muller P, Tran H, Walters BN, Young L. Recommendations for the prevention of pregnancy-associated venous thromboembolism. Aust N Z J Obstet Gynaecol 52: 3-13, 2012

Morel-Kopp MC, Tan CW, Brighton TA, McRae S, Baker R, Tran H, Mollee P, Kershaw G, Joseph J, Ward C. Validation of whole blood impedance aggregometry as a new diagnostic tool for HIT: results of a large Australian study. Thromb Haemost 107: 575-583, 2012

Nasr N, Maddocks S, Turville SG, Harman AN, Woolger N, Helbig KJ, Wilkinson J, Bye CR, Wright TK, Rambukwelle D, Donaghy H, Beard MR, Cunningham AL. HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood 120: 778-788, 2012

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Nieborowska-Skorska M, Kopinski PK, Ray R, Hoser G, Ngaba D, Flis S, Cramer K, Reddy MM, Koptyra M, Penserga T, Glodkowska-Mrowka E, Bolton E, Holyoake TL, Eaves CJ, Cerny-Reiterer S, Valent P, Hochhaus A, Hughes TP, et al. Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood 119: 4253-4263, 2012

Noll JE, Williams SA, Purton LE, Zannettino AC. Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche? Blood Cancer J 2: e91, 2012

Parker WT, Ho M, Scott HS, Hughes TP, Branford S. Poor response to second-line kinase inhibitors in chronic myeloid leukemia patients with multiple low-level mutations, irrespective of their resistance profile. Blood 119: 2234-2238, 2012

Perugini M, Iarossi DG, Kok CH, Cummings N, Diakiw SM, Brown AL, Danner S, Bardy P, Bik To L, Wei AH, Lewis ID, D'Andrea RJ. GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations. Leukemia 10.1038/leu.2012.346, 2012

Phillips RJ, Helbig KJ, Van der Hoek KH, Seth D, Beard MR. Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World J Gastroenterol 18: 3389-3399, 2012

Pitman MR, Pham DH, Pitson SM. Isoform-selective assays for sphingosine kinase activity. Methods Mol Biol 874: 21-31, 2012

Pitman MR, Woodcock JM, Lopez AF, Pitson SM. Molecular targets of FTY720 (fingolimod). Curr Mol Med 12: 1207-1219, 2012

Price KJ, Tsykin A, Giles KM, Sladic RT, Epis MR, Ganss R, Goodall GJ, Leedman PJ. Matrigel basement membrane matrix influences expression of microRNAs in cancer cell lines. Biochem Biophys Res Commun 427: 343-348, 2012

Rao N, Butcher CM, Lewis ID, Ross DM, Melo JV, Scott HS, Bardy PG, D'Andrea RJ. Clonal and lineage analysis of somatic DNMT3A and JAK2 mutations in a chronic phase polycythemia vera patient. Br J Haematol 156: 268-270, 2012

Richardson JD, Nelson AJ, Zannettino AC, Gronthos S, Worthley SG, Psaltis PJ. Optimization of the Cardiovascular Therapeutic Properties of Mesenchymal Stromal/Stem Cells-Taking the Next Step. Stem Cell Rev 10.1007/s12015-012-9366-7, 2012

Roy S, Jorgensen HG, Roy P, Abed El Baky M, Melo JV, Strathdee G, Holyoake TL, Bartholomew C. BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia. Br J Haematol 157: 446-456, 2012

Samuel MS. RAS (H-, K-, N-RAS). Encyclopedia of Signaling Molecules. Choi S. Springer. 1596-1601, 2012

Samuel MS, Olson MF. ROCK Kinases (Rho-associated coiled-coil containing protein kinase). Encyclopedia of Signaling Molecules. Choi S. Springer. 1686-1690, 2012

Sandow JJ, Jabbour AM, Condina MR, Daunt CP, Stomski FC, Green BD, Riffkin CD, Hoffmann P, Guthridge MA, Silke J, Lopez AF, Ekert PG. Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell Death Differ 19: 633-641, 2012

Schultheis B, Nijmeijer BA, Yin H, Gosden RG, Melo JV. Imatinib mesylate at therapeutic doses has no impact on folliculogenesis or spermatogenesis in a leukaemic mouse model. Leuk Res 36: 271-274, 2012

Shalini S, Dorstyn L, Wilson C, Puccini J, Ho L, Kumar S. Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice. Cell Death Differ 19: 1370-1380, 2012

Sharma A, Tan TH, Cheetham G, Scott HS, Brown MP. Rare and novel epidermal growth factor receptor mutations in non-small-cell lung cancer and lack of clinical response to gefitinib in two cases. J Thorac Oncol 7: 941-942, 2012

Sun MT, Chan W, McRae S, Selva D. Protein C deficiency with concurrent essential thrombocytosis and orbital compartment syndrome. Clin Experiment Ophthalmol 40: 325-326, 2012

Sun WY, Abeynaike LD, Escarbe S, Smith CD, Pitson SM, Hickey MJ, Bonder CS. Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent. Am J Pathol 180: 1740-1750, 2012

Sun WY, Bonder CS. Sphingolipids: a potential molecular approach to treat allergic inflammation. J Allergy (Cairo) 2012: 154174, 2012

Torpy DJ, Lundgren BA, Ho JT, Lewis JG, Scott HS, Mericq V. CBG Santiago: a novel CBG mutation. J Clin Endocrinol Metab 97: E151-155, 2012

Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C, Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A, Schuurhuis GJ, Wohrer S, Arock M, Zuber J, Cerny-Reiterer S, Johnsen HE, Andreeff M, Eaves C. Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer 12: 767-775, 2012

Vandyke K, Fitter S, Drew J, Fukumoto S, Schultz CG, Sims NA, et al. Prospective histomorphometric and DXA evaluation of bone remodeling in imatinib-treated CML patients: evidence for site-specific skeletal effects. J Clin Endocrinol Metab 98: 67-76, 2013

Wagner MC, Dziadosz M, Melo JV, Heidel F, Fischer T, Lipka DB. Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells. Leukemia 10.1038/leu.2012.364, 2012

Wang J, Hughes TP, Kok CH, Saunders VA, Frede A, Groot-Obbink K, Osborn M, Somogyi AA, D'Andrea RJ, White DL. Contrasting effects of diclofenac and ibuprofen on active imatinib uptake into leukaemic cells. Br J Cancer 106: 1772-1778, 2012

Wang X, Laan M, Bichele R, Kisand K, Scott HS, Peterson P. Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front Immunol 3: 19, 2012

Warlick E, Ahn KW, Pedersen TL, Artz A, de Lima M, Pulsipher M, Akpek G, Aljurf M, Cahn JY, Cairo M, Chen YB, Cooper B, Deol A, Giralt S, Gupta V, Khoury HJ, Kohrt H, Lazarus HM, Lewis I, et al. Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era. Blood 119: 4083-4090, 2012

Weber B, Emmert MY, Behr L, Schoenauer R, Brokopp C, Drogemuller C, Modregger P, Stampanoni M, Vats D, Rudin M, Burzle W, Farine M, Mazza E, Frauenfelder T, Zannettino AC, Zund G, Kretschmar O, Falk V, Hoerstrup SP. Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation. Biomaterials 33: 4031-4043, 2012

Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B. Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology 142: 999-1009 e1006, 2012

White DL, Brown AL, D'Andrea RJ, Rice AM. Unraveling the "known unknowns": lessons and reflections from the new directions in leukemia research 2012 conference. Cancer Res 72: 4300-4303, 2012

White DL, Hughes TP. Classification of patients with chronic myeloid leukemia on basis of BCR-ABL transcript level at 3 months fails to identify patients with low organic cation transporter-1 activity destined to have poor imatinib response. J Clin Oncol 30: 1144-1145; author reply 1145-1146, 2012

White DL, Radich J, Soverini S, Saunders VA, Frede AK, Dang P, Cilloni D, Lin P, Mongay L, Woodman R, Manley P, Slader C, Kim DW, Pane F, Martinelli G, Saglio G, Hughes TP. Chronic phase chronic myeloid leukemia patients with low OCT-1 activity randomized to high-dose imatinib achieve better responses and have lower failure rates than those randomized to standard-dose imatinib. Haematologica 97: 907-914, 2012

Yeung DT, Branford S. Monitoring disease response in chronic-phase chronic myeloid leukemia: the age of molecular assays? Hematology Am Soc Hematol Educ Program 2012: 111-114, 2012

Yeung DT, Hughes TP. Therapeutic targeting of BCR-ABL: prognostic markers of response and resistance mechanism in chronic myeloid leukaemia. Crit Rev Oncog 17: 17-30, 2012

Yin OQ, Giles FJ, Baccarani M, le Coutre P, Chiparus O, Gallagher N, Saglio G, Hughes TP, Hochhaus A, Kantarjian HM, Larson RA. Concurrent use of proton pump inhibitors or H2 blockers did not adversely affect nilotinib efficacy in patients with chronic myeloid leukemia. Cancer Chemother Pharmacol 70: 345-350, 2012

Yoshida C, Fletcher L, Ohashi K, Wakita H, Kumagai T, Shiseki M, Matsuei K, Inokuchi K, Hatta Y, Shirasugi Y, Yamaguchi T, Sakamoto J, Branford S, Sakamaki H. Harmonization of molecular monitoring of chronic myeloid leukemia therapy in Japan. Int J Clin Oncol 17: 584-589, 2012

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2011

Drini, M., N. C. Wong, H. S. Scott, J. M. Craig, A. Dobrovic, C. A. Hewitt, J. Young, R. Saffery and F. A. Macrae. "Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in Hyperplastic Polyposis Syndrome." PLoS One 6: e16831. (2011 )

Ahlgren, K. M., S. Moretti, B. A. Lundgren, I. Karlsson, E. Ahlin, A. Norling, A. Hallgren, J. Perheentupa, J. Gustafsson, F. Rorsman, P. E. Crewther, J. Ronnelid, S. Bensing, H. S. Scott, O. Kampe, L. Romani and A. Lobell. "Increased IL-17A secretion in response to Candida albicans in autoimmune polyendocrine syndrome type 1 and its animal model." Eur J Immunol 41: 235-245. (2011)

Andersen, D. C., A. Kortesidis, A. C. Zannettino, I. Kratchmarova, L. Chen, O. N. Jensen, B. Teisner, S. Gronthos, C. H. Jensen and M. Kassem. "Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells." Mol Cells 32: 133-142. (2011)

Aricha, R., T. Feferman, H. S. Scott, M. C. Souroujon, S. Berrih-Aknin and S. Fuchs. "The susceptibility of Aire(-/-) mice to experimental myasthenia gravis involves alterations in regulatory T cells." J Autoimmun 36: 16-24. (2011)

Barrett, J. M., K. A. Parham, J. B. Pippal, M. P. Cockshell, P. A. Moretti, S. L. Brice, S. M. Pitson and C. S. Bonder. "Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells." Microcirculation 18: 583-597. (2011)

Berzsenyi, M. D., D. J. Woollard, C. A. McLean, S. Preiss, V. M. Perreau, M. R. Beard, D. Scott Bowden, B. C. Cowie, S. Li, A. M. Mijch and S. K. Roberts. "Down-regulation of intra-hepatic T-cell signaling associated with GB virus C in a HCV/HIV co-infected group with reduced liver disease." J Hepatol 55: 536-544. (2011)

Boase, N. A., G. Y. Rychkov, S. L. Townley, A. Dinudom, E. Candi, A. K. Voss, T. Tsoutsman, C. Semsarian, G. Melino, F. Koentgen, D. I. Cook and S. Kumar. "Respiratory distress and perinatal lethality in Nedd4-2-deficient mice." Nat Commun 2: 287. (2011)

Bracken, C. P., J. M. Szubert, T. R. Mercer, M. E. Dinger, D. W. Thomson, J. S. Mattick, M. Z. Michael and G. J. Goodall. "Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage." Nucleic Acids Res 39: 5658-5668. (2011)

Branford, S. and T. P. Hughes. "Mutational analysis in chronic myeloid leukemia: when and what to do?" Curr Opin Hematol 18: 111-116. (2011)

Butcher, C. M., P. J. Neufing, L. Eriksson, C. L. Carmichael, E. J. Wilkins, J. V. Melo, I. D. Lewis, P. G. Bardy, H. S. Scott and R. J. D'Andrea. "RUNX1 mutations are rare in chronic phase polycythaemia vera." Br J Haematol 153: 672-675. (2011)

Cariboni, A., K. Davidson, E. Dozio, F. Memi, Q. Schwarz, F. Stossi, J. G. Parnavelas and C. Ruhrberg. "VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels." Development 138: 3723-3733. (2011)

Cortes, J., A. Hochhaus, T. Hughes and H. Kantarjian. "Front-line and salvage therapies with tyrosine kinase inhibitors and other treatments in chronic myeloid leukemia." J Clin Oncol 29: 524-531. (2011)

Dalton, H. E., D. Denton, N. J. Foot, K. Ho, K. Mills, C. Brou and S. Kumar. "Drosophila Ndfip is a novel regulator of Notch signaling." Cell Death Differ 18: 1150-1160. (2011)

Dharmapatni, A. A., M. D. Smith, T. N. Crotti, C. A. Holding, C. Vincent, H. M. Weedon, A. C. Zannettino, T. S. Zheng, D. M. Findlay, G. J. Atkins and D. R. Haynes. "TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis." Arthritis Res Ther 13: R51. (2011)

Engler, J. R., T. P. Hughes and D. L. White. "OCT-1 as a determinant of response to antileukemic treatment." Clin Pharmacol Ther 89: 608-611. (2011)

Engler, J. R., A. C. Zannettino, C. G. Bailey, J. E. Rasko, T. P. Hughes and D. L. White. "OCT-1 function varies with cell lineage but is not influenced by BCR-ABL." Haematologica 96: 213-220. (2011)

Erskine, L., S. Reijntjes, T. Pratt, L. Denti, Q. Schwarz, J. M. Vieira, B. Alakakone, D. Shewan and C. Ruhrberg. "VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm." Neuron 70: 951-965. (2011)

Esposito, N., I. Colavita, C. Quintarelli, A. R. Sica, A. L. Peluso, L. Luciano, M. Picardi, L. Del Vecchio, T. Buonomo, T. P. Hughes, D. White, J. P. Radich, D. Russo, S. Branford, G. Saglio, J. V. Melo, R. Martinelli, M. Ruoppolo, T. Kalebic, G. Martinelli and F. Pane. "SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia." Blood 118: 3634-3644. (2011)

Fantin, A., Q. Schwarz, K. Davidson, E. M. Normando, L. Denti and C. Ruhrberg. "The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins." Development 138: 4185-4191. (2011)

Fasquelle, L., H. S. Scott, M. Lenoir, J. Wang, G. Rebillard, S. Gaboyard, S. Venteo, F. Francois, A. L. Mausset-Bonnefont, S. E. Antonarakis, E. Neidhart, C. Chabbert, J. L. Puel, M. Guipponi and B. Delprat. "Tmprss3, a Transmembrane Serine Protease Deficient in Human DFNB8/10 Deafness, Is Critical for Cochlear Hair Cell Survival at the Onset of Hearing." J Biol Chem 286: 17383-17397. (2011)

Foot, N. J., Y. A. Leong, L. E. Dorstyn, H. E. Dalton, K. Ho, L. Zhao, M. D. Garrick, B. Yang, D. Hiwase and S. Kumar. "Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis." Blood 117: 638-646. (2011)

Francois, M., N. L. Harvey and B. M. Hogan. "The transcriptional control of lymphatic vascular development." Physiology (Bethesda) 26: 146-155. (2011)

Galluzzi, L., I. Vitale, J. M. Abrams, E. S. Alnemri, E. H. Baehrecke, M. V. Blagosklonny, T. M. Dawson, V. L. Dawson, W. S. El-Deiry, S. Fulda, E. Gottlieb, D. R. Green, M. O. Hengartner, O. Kepp, R. A. Knight, S. Kumar, S. A. Lipton, X. Lu, F. Madeo, W. Malorni, P. Mehlen, G. Nunez, M. E. Peter, M. Piacentini, D. C. Rubinsztein, Y. Shi, H. U. Simon, P. Vandenabeele, E. White, J. Yuan, B. Zhivotovsky, G. Melino and G. Kroemer. "Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012." Cell Death Differ (2011)

Gregory, P. A., C. P. Bracken, E. Smith, A. G. Bert, J. A. Wright, S. Roslan, M. Morris, L. Wyatt, G. Farshid, Y. Y. Lim, G. J. Lindeman, M. F. Shannon, P. A. Drew, Y. Khew-Goodall and G. J. Goodall. "An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition." Mol Biol Cell 22: 1686-1698. (2011)

Gronthos, S. and A. C. Zannettino. "Methods for the purification and characterization of human adipose-derived stem cells." Methods Mol Biol 702: 109-120. (2011)

Hahn, C. N., C. E. Chong, C. L. Carmichael, E. J. Wilkins, P. J. Brautigan, X. C. Li, M. Babic, M. Lin, A. Carmagnac, Y. K. Lee, C. H. Kok, L. Gagliardi, K. L. Friend, P. G. Ekert, C. M. Butcher, A. L. Brown, I. D. Lewis, L. B. To, A. E. Timms, J. Storek, S. Moore, M. Altree, R. Escher, P. G. Bardy, G. K. Suthers, R. J. D'Andrea, M. S. Horwitz and H. S. Scott. "Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia." Nat Genet 43: 1012-1017. (2011)

Hahn, C. N., C.-E. Chong, C. L. Carmichael, E. J. Wilkins, P. J. Brautigan, X.-C. Li, M. Babic, M. Lin, A. Carmagnac, Y. K. Lee, C. M. Butcher, K. L. Friend, P. G. Ekert, C. H. Kok, L. Gagliardi, A. L. Brown, I. D. Lewis, L. B. To, A. E. Timms, J. Storek, S. Moore, M. Altree, R. Escher, P. G. Bardy, G. K. Suthers, R. J. D'Andrea, M. S. Horwitz and H. S. Scott. "Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia." Nature Genetics accepted in principle (07/06/2011): (2011)

Harvey, N. L. "To sprout or "Notch" to sprout?" Blood 118: 836-837. (2011

Helbig, K. J., N. S. Eyre, E. Yip, S. Narayana, K. Li, G. Fiches, E. M. McCartney, R. K. Jangra, S. M. Lemon and M. R. Beard. "The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A." Hepatology 54: 1506-1517. (2011)

Herbert, K. E., J. P. Levesque, A. K. Mills, D. J. Gottlieb, J. Cooney, J. Szer, J. Rasko and L. B. To. "How we mobilize haemopoietic stem cells." Intern Med J 41: 588-594. (2011)

Hiwase, D. K., D. T. Yeung and D. L. White. "Optimizing the selection of kinase inhibitors for chronic myeloid leukemia patients." Expert Rev Hematol 4: 285-299. (2011)

Hodge, G., J. Scott, M. Osborn, L. B. To, H. Zola, S. Hodge and T. Revesz. "Increased T regulatory cells and decreased Th1 pro-inflammatory cytokines correlate with culture-positive infection in febrile neutropenia childhood oncology patients." Cytokine 53: 286-288. (2011)

Hubert, F. X., S. A. Kinkel, G. M. Davey, B. Phipson, S. N. Mueller, A. Liston, A. I. Proietto, P. Z. Cannon, S. Forehan, G. K. Smyth, L. Wu, C. C. Goodnow, F. R. Carbone, H. S. Scott and W. R. Heath. "Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance." Blood 118: 2462-2472. (2011)

Jabbour, E., G. Saglio, T. P. Hughes and H. Kantarjian. "Suboptimal responses in chronic myeloid leukemia: Implications and management strategies." Cancer (2011)

Jessup, C. F., C. S. Bonder, S. M. Pitson and P. T. Coates. "The Sphingolipid Rheostat: A Potential Target for Improving Pancreatic Islet Survival and Function." Endocr Metab Immune Disord Drug Targets (2011)

Juarez, J. G., N. Harun, M. Thien, R. Welschinger, R. Baraz, A. Dela Pena, S. M. Pitson, M. Rettig, J. F. Dipersio, K. F. Bradstock and L. J. Bendall. "Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice." Blood (2011)

Kantarjian, H. M., F. J. Giles, K. N. Bhalla, J. Pinilla-Ibarz, R. A. Larson, N. Gattermann, O. G. Ottmann, A. Hochhaus, J. P. Radich, G. Saglio, T. P. Hughes, G. Martinelli, D. W. Kim, Y. Shou, N. J. Gallagher, R. Blakesley, M. Baccarani, J. Cortes and P. D. le Coutre. "Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results." Blood 117: 1141-1145. (2011)

Kantarjian, H. M., A. Hochhaus, G. Saglio, C. De Souza, I. W. Flinn, L. Stenke, Y. T. Goh, G. Rosti, H. Nakamae, N. J. Gallagher, A. Hoenekopp, R. E. Blakesley, R. A. Larson and T. P. Hughes. "Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial." Lancet Oncol 12: 841-851. (2011)

Kont, V., A. Murumagi, L. O. Tykocinski, S. A. Kinkel, K. E. Webster, K. Kisand, L. Tserel, M. Pihlap, P. Strobel, H. S. Scott, A. Marx, B. Kyewski and P. Peterson. "DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues." Mol Immunol 49: 518-526. (2011)

Kraft, M., I. C. Cirstea, A. K. Voss, T. Thomas, I. Goehring, B. N. Sheikh, L. Gordon, H. Scott, G. K. Smyth, M. R. Ahmadian, U. Trautmann, M. Zenker, M. Tartaglia, A. Ekici, A. Reis, H.-G. Dörr, A. Rauch and C. T. Thiel. "Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice." The Journal of Clinical Investigation 121: 3479-3491. (2011)

Leclercq, T. M., P. A. Moretti and S. M. Pitson. "Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis." Oncogene 30: 372-378. (2011)

Lee, I. H., S. H. Song, C. R. Campbell, S. Kumar, D. I. Cook and A. Dinudom. "Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11." J Biol Chem 286: 19259-19269. (2011)

Ling, K. H., P. J. Brautigan, C. N. Hahn, T. Daish, J. R. Rayner, P. S. Cheah, J. M. Raison, S. Piltz, J. R. Mann, D. M. Mattiske, P. Q. Thomas, D. L. Adelson and H. S. Scott. "Deep sequencing analysis of the developing mouse brain reveals a novel microRNA." BMC Genomics 12: 176. (2011)

Ling, K. H., C. A. Hewitt, T. Beissbarth, L. Hyde, P. S. Cheah, G. K. Smyth, S. S. Tan, C. N. Hahn, T. Thomas, P. Q. Thomas and H. S. Scott. "Spatiotemporal Regulation of Multiple Overlapping Sense and Novel Natural Antisense Transcripts at the Nrgn and Camk2n1 Gene Loci during Mouse Cerebral Corticogenesis." Cereb Cortex 21: 683-697. (2011)

Mahindra, A., M. E. Kalaycio, J. Vela-Ojeda, D. H. Vesole, M. J. Zhang, P. Li, J. R. Berenson, J. M. Bird, A. Dispenzieri, J. L. Gajewski, R. P. Gale, L. Holmberg, S. Kumar, R. A. Kyle, H. M. Lazarus, S. Lonial, J. Mikhael, G. A. Milone, R. Munker, R. Nath, S. Saccaro, L. B. To, D. T. Vogl, B. Wirk and P. Hari. "Hematopoietic cell transplantation for primary plasma cell leukemia: results from the Center for International Blood and Marrow Transplant Research." Leukemia (2011)

Martin, S. K., P. Diamond, S. Gronthos, D. J. Peet and A. C. Zannettino. "The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma." Leukemia 25: 1533-1542. (2011)

Matsushima, K., H. Isomoto, N. Yamaguchi, N. Inoue, H. Machida, T. Nakayama, T. Hayashi, M. Kunizaki, S. Hidaka, T. Nagayasu, M. Nakashima, K. Ujifuku, N. Mitsutake, A. Ohtsuru, S. Yamashita, M. Korpal, Y. Kang, P. A. Gregory, G. J. Goodall, S. Kohno and K. Nakao. "MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells." J Transl Med 9: 30. (2011)

McCartney, E. M., N. S. Eyre and M. R. Beard. "Border patrol intensifies for hepatitis C virus entry." Hepatology 54: 1472-1475. (2011)

McInnes, N., T. J. Sadlon, C. Y. Brown, S. Pederson, M. Beyer, J. L. Schultze, S. McColl, G. J. Goodall and S. C. Barry. "FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells." Oncogene (2011)

Nath, S. V., I. Nicholson, H. Tapp, H. Zola, A. C. Zannettino and T. Revesz. "Reticulin fibres anchor leukaemic blasts in the marrow of patients with acute lymphoblastic leukaemia." Med Hypotheses 77: 333-335. (2011)

Ng, L. G., J. S. Qin, B. Roediger, Y. Wang, R. Jain, L. L. Cavanagh, A. L. Smith, C. A. Jones, M. de Veer, M. A. Grimbaldeston, E. N. Meeusen and W. Weninger. "Visualizing the neutrophil response to sterile tissue injury in mouse dermis reveals a three-phase cascade of events." J Invest Dermatol 131: 2058-2068. (2011)

Parker, W. T., R. M. Lawrence, M. Ho, D. L. Irwin, H. S. Scott, T. P. Hughes and S. Branford. "Sensitive Detection of BCR-ABL1 Mutations in Patients With Chronic Myeloid Leukemia After Imatinib Resistance Is Predictive of Outcome During Subsequent Therapy." J Clin Oncol (2011)

Pchejetski, D., J. Nunes, K. Coughlan, H. Lall, S. M. Pitson, J. Waxman and V. V. Sumbayev. "The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1alpha protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6." Immunol Cell Biol 89: 268-274. (2011)

Penko, D., D. Mohanasundaram, S. Sen, C. Drogemuller, C. Mee, C. S. Bonder, P. T. Coates and C. F. Jessup. "Incorporation of endothelial progenitor cells into mosaic pseudoislets." Islets 3: 73-79. (2011)

Pitman, M. R., R. K. Barr, B. L. Gliddon, A. M. Magarey, P. A. Moretti and S. M. Pitson. "A critical role for the protein phosphatase 2A B'alpha regulatory subunit in dephosphorylation of sphingosine kinase 1." Int J Biochem Cell Biol 43: 342-347. (2011)

Pitson, S. M. "Regulation of sphingosine kinase and sphingolipid signaling." Trends Biochem Sci 36: 97-107. (2011)

Pitson, S. M., J. A. Powell and C. S. Bonder. "Regulation of Sphingosine Kinase in Hematological Malignancies and Other Cancers." Anticancer Agents Med Chem (2011)

Pomie, C., R. Vicente, Y. Vuddamalay, B. A. Lundgren, M. van der Hoek, G. Enault, J. Kagan, N. Fazilleau, H. S. Scott, P. Romagnoli and J. P. van Meerwijk. "Autoimmune regulator (AIRE)-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis." Proc Natl Acad Sci U S A 108: 12437-12442. (2011)

Psaltis, P. J., A. Carbone, D. P. Leong, D. H. Lau, A. J. Nelson, T. Kuchel, T. Jantzen, J. Manavis, K. Williams, P. Sanders, S. Gronthos, A. C. Zannettino and S. G. Worthley. "Assessment of myocardial fibrosis by endoventricular electromechanical mapping in experimental nonischemic cardiomyopathy." Int J Cardiovasc Imaging 27: 25-37. (2011)

Ross, D. M., T. P. Hughes and J. V. Melo. "Do we have to kill the last CML cell?" Leukemia 25: 193-200. (2011)

Sandow, J. J., A. M. Jabbour, M. R. Condina, C. P. Daunt, F. C. Stomski, B. D. Green, C. D. Riffkin, P. Hoffmann, M. A. Guthridge, J. Silke, A. F. Lopez and P. G. Ekert. "Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death." Cell Death Differ (2011)

See, F., T. Seki, P. J. Psaltis, H. P. Sondermeijer, S. Gronthos, A. C. Zannettino, K. M. Govaert, M. D. Schuster, P. A. Kurlansky, D. J. Kelly, H. Krum and S. Itescu. "Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia." J Cell Mol Med 15: 2117-2129. (2011)

Sen, S., S. P. McDonald, P. T. Coates and C. S. Bonder. "Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease." Clin Sci (Lond) 120: 263-283. (2011)

Shandala, T., J. M. Woodcock, Y. Ng, L. Biggs, E. M. Skoulakis, D. A. Brooks and A. F. Lopez. "Drosophila 14-3-3epsilon has a crucial role in anti-microbial peptide secretion and innate immunity." J Cell Sci 124: 2165-2174. (2011)

Siow, D. L., C. D. Anderson, E. V. Berdyshev, A. Skobeleva, V. Natarajan, S. M. Pitson and B. W. Wattenberg. "Sphingosine kinase localization in the control of sphingolipid metabolism." Adv Enzyme Regul 51: 229-244. (2011)

Stein, A. M., D. Bottino, V. Modur, S. Branford, J. Kaeda, J. M. Goldman, T. P. Hughes, J. P. Radich and A. Hochhaus. "BCR-ABL Transcript Dynamics Support the Hypothesis That Leukemic Stem Cells Are Reduced during Imatinib Treatment." Clin Cancer Res (2011)

Suzuki, K., T. Ishida, M. Yamagishi, C. Ahlenstiel, S. Swaminathan, K. Marks, D. Murray, E. M. McCartney, M. R. Beard, M. Alexander, D. F. Purcell, D. A. Cooper, T. Watanabe and A. D. Kelleher. "Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific." RNA Biol 8: (2011)

Tang, C., L. Schafranek, D. B. Watkins, W. T. Parker, S. Moore, J. A. Prime, D. L. White and T. P. Hughes. "Tyrosine kinase inhibitor resistance in chronic myeloid leukemia cell lines: investigating resistance pathways." Leuk Lymphoma 52: 2139-2147. (2011)

Terao, M., M. Fratelli, M. Kurosaki, A. Zanetti, V. Guarnaccia, G. Paroni, A. Tsykin, M. Lupi, M. Gianni, G. J. Goodall and E. Garattini. "Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets." J Biol Chem 286: 4027-4042. (2011)

Thomson, D. W., C. P. Bracken and G. J. Goodall. "Experimental strategies for microRNA target identification." Nucleic Acids Res 39: 6845-6853. (2011)

To, L. B., J. P. Levesque and K. E. Herbert. "How I treat patients who mobilize hematopoietic stem cells poorly." Blood 118: 4530-4540. (2011)

To, L. B., J. P. Levesque, K. E. Herbert, I. G. Winkler, L. J. Bendall, D. K. Hiwase, V. Antonenas, A. M. Rice, D. Gottlieb, A. K. Mills, J. E. Rasko, S. Larsen, A. Beligaswatte, S. K. Nilsson, J. P. Cooney, A. C. Cambareri and I. D. Lewis. "Mobilisation strategies for normal and malignant cells." Pathology 43: 547-565. (2011)

Torpy, D. J., B. A. Lundgren, J. T. Ho, J. G. Lewis, H. S. Scott and V. Mericq. "CBG Santiago: a novel CBG mutation." J Clin Endocrinol Metab Accepted 21/9/2011: (2011)

Valdivia, L. E., R. M. Young, T. A. Hawkins, H. L. Stickney, F. Cavodeassi, Q. Schwarz, L. M. Pullin, R. Villegas, E. Moro, F. Argenton, M. L. Allende and S. W. Wilson. "Lef1-dependent Wnt/beta-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development." Development 138: 3931-3941. (2011)

Wang, Z., Y. Zhao, E. Smith, G. J. Goodall, P. A. Drew, T. Brabletz and C. Yang. "Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b." Toxicol Sci 121: 110-122. (2011)

Wati, S., S. M. Rawlinson, R. A. Ivanov, L. Dorstyn, M. R. Beard, D. A. Jans, S. M. Pitson, C. J. Burrell, P. Li and J. M. Carr. "Tumour necrosis factor alpha (TNF-alpha) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-alpha to activate nuclear factor kappaB and reduced sphingosine kinase-1 activity." J Gen Virol 92: 807-818. (2011)

White, D. L. and T. P. Hughes. "Predicting the response of CML patients to tyrosine kinase inhibitor therapy." Curr Hematol Malig Rep 6: 88-95. (2011)

Yang, Y., Y. H. Ahn, D. L. Gibbons, Y. Zang, W. Lin, N. Thilaganathan, C. A. Alvarez, D. C. Moreira, C. J. Creighton, P. A. Gregory, G. J. Goodall and J. M. Kurie. "The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice." J Clin Invest 121: 1373-1385. (2011)

Yeung, D. T. and D. L. White. "Imatinib trough levels in chronic myelogenous leukemia: does one dose fit all?" Leuk Lymphoma 52: 165-167. (2011)

Yu, C., B. Fedoric, P. H. Anderson, A. F. Lopez and M. A. Grimbaldeston. "Vitamin D(3) signalling to mast cells: A new regulatory axis." Int J Biochem Cell Biol 43: 41-46. (2011)

Yuan, S., X. Yu, M. Topf, L. Dorstyn, S. Kumar, S. J. Ludtke and C. W. Akey. "Structure of the Drosophila apoptosome at 6.9 a resolution." Structure 19: 128-140. (2011)

Zamudio, N. M., H. S. Scott, K. Wolski, C. Y. Lo, C. Law, D. Leong, S. A. Kinkel, S. Chong, D. Jolley, G. K. Smyth, D. de Kretser, E. Whitelaw and M. K. O'Bryan. "DNMT3L Is a Regulator of X Chromosome Compaction and Post-Meiotic Gene Transcription." PLoS One 6: e18276. (2011)

Zinonos, I., A. Labrinidis, M. Lee, V. Liapis, S. Hay, V. Ponomarev, P. Diamond, D. M. Findlay, A. C. Zannettino and A. Evdokiou. "Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo." J Bone Miner Res 26: 630-643. (2011)

2010

Carmichael, C. L., E. J. Wilkins, H. Bengtsson, M. S. Horwitz, T. P. Speed, P. C. Vincent, G. Young, C. N. Hahn, R. Escher and H. S. Scott. "Poor prognosis in familial acute myeloid leukaemia with combined biallelic CEBPA mutations and downstream events affecting the ATM, FLT3 and CDX2 genes." British Journal of Haematology 150: 382-385. (2010)

Cowin, P. A., E. Gold, J. Aleksova, M. K. O'Bryan, P. M. D. Foster, H. S. Scott and G. P. Risbridger. "Vinclozolin Exposure in Utero Induces Postpubertal Prostatitis and Reduces Sperm Production via a Reversible Hormone-Regulated Mechanism." Endocrinology 151: 783-792. (2010)

George, A. J., L. Gordon, T. Beissbarth, I. Koukoulas, R. M. D. Holsinger, V. Perreau, R. Cappai, S. S. Tan, C. L. Masters, H. S. Scott and Q. X. Li. "A Serial Analysis of Gene Expression Profile of the Alzheimer's Disease Tg2576 Mouse Model." Neurotoxicity Research 17: 360-379. (2010)

Guipponi, M., Q. X. Li, L. Hyde, T. Beissbarth, G. K. Smyth, C. L. Masters and H. S. Scott. "SAGE Analysis of Genes Differentially Expressed in Presymptomatic TgSOD1(G93A) Transgenic Mice Identified Cellular Processes Involved in Early Stage of ALS Pathology." Journal of Molecular Neuroscience 41: 172-182. (2010)

Hanifa, S., H. S. Scott, P. Crewther, M. Guipponi and J. Tan. "Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice." Neuroreport 21: 897-901. (2010)

Hewitt, C. A., K. H. Ling, T. D. Merson, K. M. Simpson, M. E. Ritchie, S. L. King, M. A. Pritchard, G. K. Smyth, T. Thomas, H. S. Scott and A. K. Voss. "Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome." Plos One 5: e11561. (2010)

Jongmans, M. C. J., R. P. Kuiper, C. L. Carmichael, E. J. Wilkins, N. Dors, A. Carmagnac, A. Y. N. Schouten-van Meeteren, X. Li, M. Stankovic, E. Kamping, H. Bengtsson, E. Schoenmakers, A. G. van Kessel, P. M. Hoogerbrugge, C. N. Hahn, P. P. Brons, H. S. Scott and N. Hoogerbrugge. "Novel RUNX1 mutations in familial platelet disorder with enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndrome." Leukemia 24: 242-246. (2010)

Kedzierska, K., S. A. Valkenburg, C. Guillonneau, F. X. Hubert, T. Cukalac, J. M. Curtis, J. Stambas, H. S. Scott, L. Kedzierski, V. Venturi and M. P. Davenport. "Diversity and clonotypic composition of influenza-specific CD8(+) TCR repertoires remain unaltered in the absence of Aire." European Journal of Immunology 40: 849-858. (2010)

Kelly, R. M., E. M. Goren, P. A. Taylor, S. N. Mueller, H. E. Stefanski, M. J. Osborn, H. S. Scott, E. A. Komarova, A. V. Gudkov, G. A. Hollander and B. R. Blazar. "Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation." Blood 115: 1088-1097. (2010)

Ko, H. J., S. A. Kinkel, F. X. Hubert, Z. Nasa, J. Chan, C. Siatskas, P. Hirubalan, B. H. Toh, H. S. Scott and F. Alderuccio. "Transplantation of autoimmune regulator-encoding bone marrow cells delays the onset of experimental autoimmune encephalomyelitis." Eur J Immunol 40: 3499-3509. (2010)

Milicevic, Z., N. M. Milicevic, M. Laan, P. Peterson, K. Kisand, H. S. Scott and J. Westermann. "Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)-deficient mice." Immunology and Cell Biology 88: 50-56. (2010)

Shi, W., C. A. de Graaf, S. A. Kinkel, A. H. Achtman, T. Baldwin, L. Schofield, H. S. Scott, D. J. Hilton and G. K. Smyth. "Estimating the proportion of microarray probes expressed in an RNA sample." Nucleic Acids Research 38: 2168-2176. (2010)

Wilson S, Milne I, Bagley CJ, Gamble JR, Vadas MA, Pitson SM and Khew-Goodall Y."A novel pro-inflammatory role for neutrophil-derived N-terminally truncated Annexin A1 in neutrophil transendothelial migration." J Immunol.  185:3057-63. (2010)

Biggs, L., C. Yu, B. Fedoric, A. F. Lopez, S. J. Galli and M. A. Grimbaldeston. "Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice." J Exp Med 207: 455-463. (2010)

Dalton, H. E., D. Denton, N. J. Foot, K. Ho, K. Mills, C. Brou and S. Kumar. "Drosophila Ndfip is a novel regulator of Notch signaling." Cell Death Differ (2010)

Denton, D., B. Shravage, R. Simin, E. H. Baehrecke and S. Kumar. "Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy." Autophagy 6: 163-165. (2010)

Fantin, A., J. M. Vieira, G. Gestri, L. Denti, Q. Schwarz, S. Prykhozhij, F. Peri, S. W. Wilson and C. Ruhrberg. "Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction." Blood 116: 829-840. (2010)

Gordon, E. J., S. Rao, J. W. Pollard, S. L. Nutt, R. A. Lang and N. L. Harvey. "Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation." Development 137: 3899-3910. (2010)

Hiwase, D. K., D. L. White, J. A. Powell, V. A. Saunders, S. A. Zrim, A. K. Frede, M. A. Guthridge, A. F. Lopez, R. J. D'Andrea, L. B. To, J. V. Melo, S. Kumar and T. P. Hughes. "Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors." Leukemia 24: 771-778. (2010)

Kazenwadel, J., M. Z. Michael and N. L. Harvey. "Prox1 expression is negatively regulated by miR-181 in endothelial cells." Blood 116: 2395-2401. (2010)

Khew-Goodall, Y. and G. J. Goodall. "Myc-modulated miR-9 makes more metastases." Nat Cell Biol 12: 209-211. (2010)

Kim, S., M. Prout, H. Ramshaw, A. F. Lopez, G. LeGros and B. Min. "Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3." J Immunol 184: 1143-1147. (2010)

Liu, B., L. Liu, A. Tsykin, G. J. Goodall, J. E. Green, M. Zhu, C. H. Kim and J. Li. "Identifying functional miRNA-mRNA regulatory modules with correspondence latent dirichlet allocation." Bioinformatics 26: 3105-3111. (2010)

Lopez, A. F., T. R. Hercus, P. Ekert, D. R. Littler, M. Guthridge, D. Thomas, H. S. Ramshaw, F. Stomski, M. Perugini, R. D'Andrea, M. Grimbaldeston and M. W. Parker. "Molecular basis of cytokine receptor activation." IUBMB Life 62: 509-518. (2010)

Manning, J. A. and S. Kumar. "A potential role for Nedd1 and the centrosome in senescence of mouse embryonic fibroblasts." Cell Death & Disease 1: e35 (2010)

Manning, J. A., M. Lewis, S. A. Koblar and S. Kumar. "An essential function for the centrosomal protein NEDD1 in zebrafish development." Cell Death Differ 17: 1302-1314. (2010)

Manning, J. A., S. Shalini, J. M. Risk, C. L. Day and S. Kumar. "A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome." PLoS One 5: e9618. (2010)

Mercer, T. R., M. E. Dinger, C. P. Bracken, G. Kolle, J. M. Szubert, D. J. Korbie, M. E. Askarian-Amiri, B. B. Gardiner, G. J. Goodall, S. M. Grimmond and J. S. Mattick. "Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome." Genome Res 20: 1639-1650. (2010)

Perugini, M., A. L. Brown, D. G. Salerno, G. W. Booker, C. Stojkoski, T. R. Hercus, A. F. Lopez, M. L. Hibbs, T. J. Gonda and R. J. D'Andrea. "Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit." Blood 115: 3346-3353. (2010)

Prim, J. M., F. J. Barcala, J. P. Esquete, A. P. Reino, A. F. Lopez and L. V. Cuadrado. "Lung cancer in a health area of Spain: incidence, characteristics and survival." Eur J Cancer Care (Engl) 19: 227-233. (2010)

Ruhrberg, C. and Q. Schwarz. "In the beginning: Generating neural crest cell diversity." Cell Adh Migr 4: (2010)

Sadlon, T. J., B. G. Wilkinson, S. Pederson, C. Y. Brown, S. Bresatz, T. Gargett, E. L. Melville, K. Peng, R. J. D'Andrea, G. G. Glonek, G. J. Goodall, H. Zola, M. F. Shannon and S. C. Barry. "Genome-wide identification of human FOXP3 target genes in natural regulatory T cells." J Immunol 185: 1071-1081. (2010)

Schwarz, Q. and C. Ruhrberg. "Neuropilin, you gotta let me know: should I stay or should I go?" Cell Adh Migr 4: 61-66. (2010)

Vieira, J. M., C. Ruhrberg and Q. Schwarz. "VEGF receptor signaling in vertebrate development." Organogenesis 6: 97-106. (2010)

Wang, B., M. Herman-Edelstein, P. Koh, W. Burns, K. Jandeleit-Dahm, A. Watson, M. Saleem, G. J. Goodall, S. M. Twigg, M. E. Cooper and P. Kantharidis. "E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta." Diabetes 59: 1794-1802. (2010)

Woodcock, J. M., Y. Ma, C. Coolen, D. Pham, C. Jones, A. F. Lopez and S. M. Pitson. "Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function." Cell Signal 22: 1291-1299. (2010)

Wright, J. A., J. K. Richer and G. J. Goodall. "microRNAs and EMT in mammary cells and breast cancer." J Mammary Gland Biol Neoplasia 15: 213-223. (2010)

Yang, B. and S. Kumar. "Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions." Cell Death Differ 17: 68-77. (2010)

Risebro, C. A., R. G. Searles, A. A. Melville, E. Ehler, N. Jina, S. Shah, J. Pallas, M. Hubank, M. Dillard, N. L. Harvey, R. J. Schwartz, K. R. Chien, G. Oliver and P. R. Riley. "Prox1 maintains muscle structure and growth in the developing heart." Development 136: 495-505. (2009)

Schwarz, Q., C. H. Maden, K. Davidson and C. Ruhrberg. "Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia." Development 136: 1785-1789. (2009)

Schwarz, Q., C. H. Maden, J. M. Vieira and C. Ruhrberg. "Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification." Proc Natl Acad Sci U S A 106: 6164-6169. (2009)

Martin SK, Fitter S, Bong LF, Drew JJ, Gronthos S, Shepherd PR, Zannettino AC. NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells. J Bone Miner Res. 2010 Apr 30. [Epub ahead of print]

Fitter S, Vandyke K, Schultz CG, White D, Hughes TP, Zannettino AC. Plasma Adiponectin Levels Are Markedly Elevated in Imatinib-Treated Chronic Myeloid Leukemia (CML) Patients: A Mechanism for Improved Insulin Sensitivity in Type 2 Diabetic CML Patients? Clin Endocrinol Metab. 2010 May 13. [Epub ahead of print]

White DL, Hughes TP. Predicting the response of CML patients to tyrosine kinase inhibitor therapy. Curr Hematol Malig Rep. 2009 Apr;4(2):59-65.

 White DL, Dang P, Engler J, Frede A, Zrim S, Osborn M, Saunders VA, Manley PW, Hughes TP. Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib. J Clin Oncol. 2010 Jun 1;28(16):2761-7. Epub 2010 Apr 26

Williams SA, Martin SK, Vincent C, Gronthos S, Zheng T, Atkins GJ, Zannettino AC. Circulating levels of TWEAK correlate with bone erosion in multiple myeloma patients. Br J Haematol. 2010 Apr 12. [Epub ahead of print]

Pitman MR, Pitson SM. Inhibitors of the sphingosine kinase pathway as potential therapeutics. Curr Cancer Drug Targets. 2010 Jun;10(4):354-67.

Vandyke K, Dewar AL, Diamond P, Fitter S, Schultz CG, Sims NA, Zannettino AC. The tyrosine kinase inhibitor dasatinib dysregulates bone remodelling through inhibition of osteoclasts in vivo. J Bone Miner Res. 2010 Mar 11. [Epub ahead of print]

Menicanin D, Bartold PM, Zannettino AC, Gronthos S. Identification of a Common Gene Expression Signature Associated with Immature Clonal Mesenchymal Cell Populations derived from Bone Marrow and Dental Tissues. Stem Cells Dev. 2010 Feb 3. [Epub ahead of print]

2009

Campbell, I. K., S. A. Kinkel, S. F. Drake, A. van Nieuwenhuijze, F. X. Hubert, D. M. Tarlinton, W. R. Heath, H. S. Scott and I. P. Wicks. "Autoimmune Regulator Controls T Cell Help for Pathogenetic Autoantibody Production in Collagen-Induced Arthritis." Arthritis and Rheumatism 60: 1683-1693. (2009)

Carmichael, C. L., I. J. Majewski, W. S. Alexander, D. Metcalf, D. J. Hilton, C. A. Hewitt and H. S. Scott. "Hematopoietic defects in the Ts1Cje mouse model of Down syndrome." Blood 113: 1929-1937. (2009)

Fletcher, A. L., T. E. Lowen, S. Sakkal, J. J. Reiseger, M. V. Hammett, N. Seach, H. S. Scott, R. L. Boyd and A. P. Chidgey. "Ablation and Regeneration of Tolerance-Inducing Medullary Thymic Epithelial Cells after Cyclosporine, Cyclophosphamide, and Dexamethasone Treatment." Journal of Immunology 183: 823-831. (2009)

Fletcher, A. L., N. Seach, J. J. Reiseger, T. E. Lowen, M. V. Hammett, H. S. Scott and R. L. Boyd. "Reduced Thymic Aire Expression and Abnormal NF-kappa B2 Signaling in a Model of Systemic Autoimmunity." Journal of Immunology 182: 2690-2699. (2009)

Gagliardi, L., C. Hotu, G. Casey, W. J. Braund, K. H. Ling, T. Dodd, J. Manavis, P. G. Devitt, R. Cutfield, Z. Rudzki, H. S. Scott and D. J. Torpy. "Familial vasopressin-sensitive ACTH-independent macronodular adrenal hyperplasia (VPs-AIMAH): clinical studies of three kindreds." Clinical Endocrinology 70: 883-891. (2009)

Hubert, F. X., S. A. Kinkel, P. E. Crewther, P. Z. F. Cannon, K. E. Webster, M. Link, R. Uibo, M. K. O'Bryan, A. Meager, S. P. Forehan, G. K. Smyth, L. Mittaz, S. E. Antonarakis, P. Peterson, W. R. Heath and H. S. Scott. "Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype." Journal of Immunology 182: 3902-3918. (2009)

Laan, M., K. Kisand, V. Kont, K. Moll, L. Tserel, H. S. Scott and P. Peterson. "Autoimmune Regulator Deficiency Results in Decreased Expression of CCR4 and CCR7 Ligands and in Delayed Migration of CD4(+) Thymocytes." Journal of Immunology 183: 7682-7691. (2009)

Ling, K. H., C. A. Hewitt, T. Beissbarth, L. Hyde, K. Banerjee, P. S. Cheah, P. Z. Cannon, C. N. Hahn, P. Q. Thomas, G. K. Smyth, S. S. Tan, T. Thomas and H. S. Scott. "Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling." Genome Biology 10: (2009)

Milicevic, N. M., Z. Milicevic, M. D. Miljkovic, M. Labudovic-Borovic, M. Laan, P. Peterson, K. Kisand, H. Scott, N. Qu and J. Westermann. "Metallophilic macrophages are fully developed in the thymus of autoimmune regulator (Aire)-deficient mice." Histochemistry and Cell Biology 131: 643-649. (2009)

Roberts, N. A., G. E. Desanti, D. R. Withers, H. R. Scott, W. E. Jenkinson, P. J. L. Lane, E. J. Jenkinson and G. Anderson. "Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult." European Journal of Immunology 39: 2395-2402. (2009)

Martin SK, Diamond P, Williams SA, To LB, Peet DJ, Fujii N, Gronthos S, Harris AL, Zannettino AC. Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica. 2010 May;95(5):776-84. Epub 2009 Dec 16

 Hughes TP, Branford S. Monitoring disease response to tyrosine kinase inhibitor therapy in CML. Hematology Am Soc Hematol Educ Program. 2009:477-87.

 Kumar S. Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Nat Rev Cancer. Dec;9(12):897-903. 2009.

Vandyke K, Fitter S, Dewar AL, Hughes TP, Zannettino AC. Dysregulation of bone remodeling by imatinib mesylate. Blood. 2010 Jan 28;115(4):766-74. Epub 2009 Nov 4. Review.

Branford S, Melo JV, Hughes TP. Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter? Blood. 2009 Dec 24;114(27):5426-35. Epub 2009 Oct 30.

Jarman KE, Moretti PA, Zebol JR, Pitson SM. Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium and integrin binding protein 1.J Biol Chem. Oct 23. [Epub ahead of print]. 2009.

 ter Braak M, Danneberg K, Lichte K, Liphardt K, Ktistakis NT, Pitson SM, Hla T, Jakobs KH, Meyer zu Heringdorf D. Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochim Biophys Acta. May;1791(5):357-70. (2009)

Denton D, Shravage B, Simin R, Mills K, Berry DL, Baehrecke EH, Kumar S. Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Current Biology  Nov 3;19(20):1741-6. (2009)

Pitson SM, Pébay A. Regulation of stem cell pluripotency and neural differentiation by lysophospholipids. Neurosignals 17(4):242-54. (2009)

Gamble JR, Sun WY, Li X, Hahn CN, Pitson SM, Vadas MA, Bonder CS. Sphingosine Kinase-1 Associates with Integrin {alpha}V{beta}3 to Mediate Endothelial Cell Survival.Am J Pathol Nov;175(5):2217-25. 2009.

Powell JA, Thomas D, Barry EF, Kok CH, McClure BJ, Tsykin A, To LB, Brown A, Lewis ID, Herbert K, Goodall GJ, Speed TP, Asou N, Jacob B, Osato M, Haylock DN, Nilsson SK, D'Andrea RJ, Lopez AF, Guthridge MA. Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML. Blood Nov 26;114(23):4859-70. (2009)

Gibbons DL, Lin W, Creighton CJ, Rizvi ZH, Gregory PA, Goodall GJ, Thilaganathan N, Du L, Zhang Y, Pertsemlidis A, Kurie JM. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.  Genes Dev.  Sep 15;23(18):2140-51. (2009)

Lidington D, Peter BF, Meissner A, Kroetsch J, Pitson SM, Pohl U, Bolz SS. The Phosphorylation Motif at Serine 225 Governs the Localization and Function of Sphingosine Kinase 1 in Resistance Arteries.Arterioscler Thromb Vasc Biol. Nov;29(11):1916-22 (2009)

Kumar S, Dorstyn L. Analyzing caspase activation and caspase activity in apoptotic cells. In: Apoptosis Methods and Protocols (eds. Peter Erhardt and Ambrus Toth). Humana Press Inc. NJ, USA. Methods in Molecular Biology 559: 3-17. (2009)

Jin L, EM Lee, HS Ramshaw, SJ Busfield, AG Peoppl, L Wilkinson, MA Guthridge, D Thomas, EF Barry, A Boyd, DP Gearing, G Vairo, AF Lopez, JE Dick and RB Lock. Monoclonal antibody-mediated targeting of CD123 (IL-3 receptor a chain) eliminates human acute myeloid leukemic stem cells. Cell Stem Cell5(1):31-42, (2009)

Condina MR, Guthridge MA, McColl SR, Hoffmann P. A sensitive magnetic bead method for the detection and identification of tyrosine phosphorylation in proteins by MALDI-TOF/TOF MS.Proteomics Jun;9(11):3047-57 (2009)

Hercus TR, MA Guthridge, D Thomas, PG Ekert, J King-Scott, MW Parker and AF Lopez. Review: The GM-CSF receptor: linking its structure to cell signaling and its role in disease. Blood114(7):1289-1298 (2009)

Ho LH, Taylor R, Cakouros D, Dorstyn L, Bouillet P, Kumar S. A tumor suppressor function for caspase-2. Proc. Natl. Acad. Sci. USA 106: 5336-5341. (2009)

Limaye V, Vadas MA, Pitson SM, Gamble JR. The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells.Cell Mol Biol Lett. 14(3):411-23. (2009)

Limaye V, Xia P, Hahn C, Smith M, Vadas MA, Pitson SM, Gamble JR. Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells.Cell Mol Biol Lett. 114(3):424-41. (2009)

Barry EF, FA Felquer, JA Powell, L Biggs, FC Stomski, A Urbani, H Ramshaw, P Hoffmann, MC Wilce, MA Grimbaldeston, AF Lopez and MA Guthridge. 14-3-3:SHC Scaffolds Integrate Phosphoserine and Phosphotyrosine Signaling to Regulate PI 3-Kinase Activation and Cell Survival. J Biol Chem  84(18):12080-90, (2009)

Caruso M, Moore J, Goodall GJ, Thomas M, Phillis S, Tyskin A, Cheetham G, Lerda N, Takahashi H, Ruszkiewicz A. Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis.  Virchows Arch.  Mar;454(3):291-302. (2009)

Bracken C.P., Gregory P.A., Khew-Goodall Y., Goodall G.J. The role of microRNAs in metastasis and epithelial-mesenchymal transition.  Cell Mol Life Sci. May;66(10):1682-99. (2009)

Bonder CS, Sun WY, Matthews T, Cassano C, Li X, Ramshaw HS, Pitson SM, Lopez AF, Coates PT, Prioa R, Vadas MA and Gamble JR. Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood 113(9):2108-17, 2009.

Jabbour AM, JE Heraud, CP Daunt, T Kaufmann, J Sandow, LA O’Reilly, BA Callus, A Lopez, A Strasser, DL Vaux, PG Ekert. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death & Differentiation16(4):555-563, 2009.

Dorstyn L, Kumar S (2009) Putative functions of caspase-2. F1000 Report In press.

Kumar S (2009) Caspase-2 in apoptosis, DNA damage response and tumor suppression: Enigma no more? Nature Rev. Cancer In press (December).

Yang B, Kumar S (2009) Nedd4 and Nedd4-2: Closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death Differ. In press. (doi:10.1038/cdd.2009.84)

Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan S-S (2009) Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc. Natl. Acad. Sci. USA 106:15489-15494.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Ashkenazi A, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, Maria RD, Deshmukh M, Dynlacht BD, El-Deiry WS, Fulda S, Garrido C, Golstein P, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon M-L, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner M, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malorni W, Marine J-C W, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JHM, Puthalakath H, Rabinovich G, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Scorrano L, Simon H-U, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G (2009) Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 16: 1093–1107.

Kochetkova M, Kumar S, McColl S (2009) The chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells. Cell Death Differ. 16: 664-673.

Rotin D, Kumar S (2009) Physiological functions of the HECT family of ubiquitin ligases. Nature Rev. Mol. Cell Biol. 10: 398-409.

Lee I-H, Campbell CR, Song S-H, Day ML, Kumar S, Cook DI, Dinudom A (2009) The activity of the epithelial sodium channels is regulated by the caveolin-1 via a Nedd4-2 dependent mechanism. J. Biol. Chem. 284: 12663-12669.

Hiwase DK, White DL, Saunders V, Frede A, To LB, Kumar S, Melo JV, Hughes TP. Short term intense Bcr-Abl kinase inhibition with nilotinib is adequate to trigger cell death in BCR-ABL+ cells. Leukemia 23: 1205-1206. (2009)

Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, Hengartner M, Knight RA, Kumar S, Lipton SA, Malorni W, Nuñez G, Peter ME, Tschopp J, Yuan J, Piacentini M, Zhivotovsky B, Melino G (2009) Classification of cell death: Recommendations of the nomenclature committee on cell death 2009. Cell Death Differ. 16: 3-11.

Mark. R. Condina, Mark A. Guthridge, Shaun R. McColl, Peter Hoffmann. A Sensitive Magnetic Bead Approach for the Detection and Identification of Tyrosine Phosphorylation in proteins by MALDI- TOF/TOF mass spectrometry. Proteomics 9(11):3047-57, 2009

Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B, Kumar S.  Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112(10):4268-75. 2009

Barr RK, Lynn HE, Moretti PAB, Khew-Goodall Y and Pitson SM. Deactivation of human sphingosine kinase 1 via dephosphorylation by protein phosphatase 2A.J Biol Chem 283: 34994-35002, 2009