Centre for Cancer Biology
Centre for Cancer Biology
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General Enquiries

Ms Anna Nitschke
PA to Prof. Angel Lopez

Centre for Cancer Biology
SA Pathology
PO Box 14 Rundle Mall
Adelaide SA 5000
AUSTRALIA

Tel: 61 8  8222 3422
Fax:61 8  8232 4092


Email:

Anna.Nitschke@health.sa.gov.au


Professor Sharad Kumar co-director of the CCB is the winner of the Lemberg Medal 2013

28th February 2013

The Lemberg Medal is the highest honour awarded by the Australian Society for Biochemistry and Molecular Biology (ASBMB) to members. Professor Kumar will be presented his medal at the Combio Meeting in Perth in September this year.

The Lemberg Medal is awarded to a distinguished ASBMB member who will present the Lemberg Lecture at the ComBio meeting. The Medal is presented in memory of Emeritus Professor M.R. Lemberg who was the Society's first President and Honorary Member.

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Dr Michael Samuel awarded a Future Fellowship

15th August 2012

The CCB is proud to note that one of its Florey Fellow has been awarded a Future Fellowship for 4 years. Dr Samuel's project is directed at understanding the role of Rho in cell signalling and cancer progression in the skin, colon and other organs.

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CCB Researchers awarded new Cancer and Diabetes grants

20th April 2012

Dr Cameron Bracken and Prof Greg Goodall have been awarded a 3-year grant by the Association for International Cancer Research (AICR) to study the global response of microRNA target genes in epithelial-mesenchymal transition. Dr Yeesim Khew-Goodall has also been awarded a 1-year grant from Diabetes Australia Research Trust to study novel aspects of insulin signalling in Type 2 diabetes.

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Clifford Prize for Cancer Research was awarded to Vishva Dixit at the 5th Barossa Meeting

30th November 2011

The Clifford Prize for Cancer Research was awarded to Dr Vishva Dixit for his pioneering work on the machinery of cell death, which has dramatically altered our understanding of the molecular events required for programmed cell death and pro-inflammatory signalling in cancer. The prize was awarded at the 5th Barossa Meeting on the theme "Cell Signalling and Molecular Medicine", which concluded on Saturday November 26th.

The 5th Barossa Meeting continued the tradition of the Barossa “Science among the Vines” series. Guests commented that “The combination of outstanding science, this location and superb food and wine, led to a meeting that was extremely stimulating to both the intellect and the senses”. For visual impressions on the meeting please visit our Gallery.

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CCB wins 16 new NHMRC Project grants and 3 Fellowships

17th October 2011

Researchers from the Centre for Cancer Biology have been awarded $9.6 million in new NHMRC Project Grants in the 2012 round as announced this morning.

The project grant funding to Dr Claudine Bonder (2), Dr Natasha Harvey (2), Prof Sharad Kumar (2), A/Prof Michael Beard, A/Prof Sue Brandford, Prof Greg Goodall, Prof Tim Hughes, Dr Michael Samuel, Prof Hamish Scott, A/Prof Deb White, Prof Andrew Zannetino, and Prof Angel Lopez and Dr Tim Hercus (with A/Prof Paul Ekert and Dr Andrew Webb WEHI, Melbourne), and Dr Yeesim Khew-Goodall and Dr Phil Gregory (with Dr Robin Anderson, Peter Mac, Melbourne) will support research into vascular biology, ubiquitination, ion channels, ageing, lymphangiogenesis, microRNA regulation, EMT, and haematological malignancies.

The successful Fellows were Prof Hamish Scott (PRF), Prof Greg Goodall (SRF) and Dr Daniel Thomas (CJ Martin).

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Members of the CCB Faculty achieve recognition

16th October 2011

Associate Professor Greg Goodall an affiliate member of the University of Adelaide has been recognized for his excellent performance through academic promotion to Professor.

At the AusBiotech 2011 National Conference in Adelaide Dr Quenten Schwarz was awarded the SA Young Achiever Award by BioSA in recognition of his contribution to biotechnology.

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CCB Researchers awarded Senior Cancer Research Fellowships

22nd September 2011

CCB Researchers Dr Loretta Dorstyn and Dr Phillip Gregory have been awarded 3 year Senior Cancer Research Fellowships through the South Australian Cancer Research Collaborative.

Dr Loretta Dorstyn received $300,000 funding to carry out her work in the Molecular Regulation Laboratory on "Characterisation of the role and mechanisms of caspase-2 in tumour suppression”. Her study focuses on characterising the function and mechanisms of a novel tumour suppressor protein in aim to further understand the process of malignant transformation and tumorigenesis.

Dr Phillip Gregory received $285,000 funding to carry out his work in the Gene Regulation Laboratory on “Discovery and functional characterization of novel microRNAs and other non-coding RNAs that regulate epithelial-mesenchymal transition and breast cancer metastasis”. He was recently awarded the "2011 Tall Poppy Award" by the Australian Institute of Policy and Science.

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Adelaide researchers discover important familial cancer gene

4th September 2011

Researchers from the Centre for Cancer Biology at SA Pathology have led an international collaboration in identifying the inherited gene defects which predisposes some people to develop myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML).

Professor Hamish S Scott from the Centre for Cancer Biology, who has been leading the research, said that the gene is the blood cancer equivalent of a familial colon, breast or ovarian cancer gene.

The work has been published in the prestigious journal Nature Genetics and can be viewed online at http://www.nature.com/ng/index.html

The full press release can be viewed here.......

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5th Barossa Meeting

20th July 2011

Registrations have opened for the 5th Barossa Meeting to take place in the Barossa Valley from 23rd to 26th November 2011 on the theme of Cell Signalling and Molecular Medicine:
http://www.sapmea.asn.au/conventions/signalling2011/index.html.

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Call for nominations for the Clifford Prize for Cancer Research

20th July 2011

The Clifford Prize for Cancer Research is an International Prize that we instituted in 2005 to award those exceptional individuals whose outstanding cancer research can lead to significant clinical outcomes. The Prize, awarded at the biennial “Barossa Science Amongst the Vines” conference, consists of a Perpetual Trophy, an ad hominem glass sculpture and a magnum of Australia’s most famous wine Penfold’s “Grange Hermitage”.

Previous awardees were Axel Ullrich (2005), Tony Hunter (2007) and John Dick (2009) for their pioneering work in targeted therapies for cancer. The 2011 Prize will be awarded at the Fifth Barossa Meeting ‘Cell Signalling and Molecular Medicine’ to be conducted 23-26 November 2011 in the Barossa Valley, South Australia.

Nominations for the award should include a brief description of the candidate’s contributions to cancer research, highlighting the impact of the work on cancer treatment. Nominations should be submitted by the 31st August by mail or email to:

Anna Nitschke
Executive Assistant to Professor AF Lopez
Director, Centre for Cancer Biology
Head, Human Immunology, SA Pathology
Frome Road, Adelaide SA 5000
Australia
T: +61 8 8222 3422
F: +61 8 8232 4092
E: Anna.Nitschke@health.sa.gov.au
W: centreforcancerbiology.org.au

Note that it is a requirement that the recipient of the award attends the Fifth Barossa Meeting to receive the award and to present a talk describing the work that has led to the award. Nominees will be judged by an independent panel of Australian Scientists

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CCB holds inaugural AGM

16th June 2011

Two years after its inception the Centre for Cancer Biology held its inaugural Annual General Meeting. Guest speakers were the Honourable John Hill MP, Minister for Health and Professor Joe Trapani, Director of Research at Peter MacCallum Cancer Centre who congratulated the Centre for its vision and achievements to date. The CCB Annual Report can be down loaded here ...CCB_Annual_Report_2010.pdf

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A/Prof Stuart Pitson wins 2011 ASBMB Merck Research Excellence Medal

9th February 2011

Associate Professor Stuart Pitson, a senior faculty member of the Centre for Cancer Biology, was awarded today the prestigious ASBMB Merck Research Excellence Medal. This Australia wide prize is awarded annually to a biochemist or molecular biologist in recognition of distinguished contributions to his/her field, based on work carried out predominantly within Australia. Congratulations to Associate Professor Pitson and his team.

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Members of the CCB achieve recognition

17th January 2011

Prof Hamish Scott, A/Prof D White and S Branford have been awarded Founding Fellowships of the Faculty of Science of the Royal College of Pathologists of Australasia; whilst A/Prof G Goodall has become an Editorial Member of “Oncogene”.

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CCB wins new funding for its cancer research

10th January 2011

Members of the Centre for Cancer Biology have been awarded over $1.5 million in research funding to study the causes and mechanisms underlying breast cancer, prostate cancer and leukaemia. Drs D White, Y Khew-Goodall, N Harvey and J Melo are the successful recipients of 1 year grants from the Cancer Council of SA; D White and T Hughes obtained a 1 year grant from the Leukaemia Foundation of Australia; Prof A Lopez and Dr H Ramshaw (in collaboration with Prof C Mullighan) and A/Prof G Goodall (in collaboration with Prof W Tilley) were awarded 3 year grants from Cancer Australia.

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CCB Faculty members win promotions

4th January 2011

CCB Faculty Members, Associate Professor Andrew Zannettino, Dr Stuart Pitson and Dr Deborah White, who are also affiliate members of the University of Adelaide, have been recognized for their excellent performance through academic promotions.

The affiliate status of Professor to Associate Professor Andrew Zannettino, and of Associate Professor to Drs Stuart Pitson and Deborah White were conferred.

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CCB Co-Director Professor Sharad Kumar wins the prestigious Ranbaxy Research Award 2009

14th November 2010

This much coveted international award recognises the best scientists of Indian origin. Prof Kumar's award was in the Medical Sciences – Basic Research category. Prof Kumar was also re-appointed as a NHMRC Senior Principal Research Fellow.

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CCB wins 10 new NHMRC project grants

12th November 2010

Scientists from the Centre for Cancer Biology have attracted over $5 million in new NHMRC project grants in the 2010 round as announced on Friday by the NHMRC. The funding to A/Prof Gregory Goodall (2), Prof Hamish Scott (2), Dr Michele Grimbaldeston (2), Prof Sharad Kumar, Dr Stuart Pitson, Dr Mark Guthridge and Dr Quenten Schwarz will support research into microRNA regulation, EMT, haematological malignancies, sphingosine kinase, mast cells and neurobiology.

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Dr Claudine Bonder wins National Heart Foundation Fellowship

15th October 2010

Dr Claudine Bonder, Head of the Vascular Biology Laboratory of the CCB, has been awarded a prestigious Research Fellowship by the National Heart Foundation. These are highly competitive fellowships intended to recognize and enhance the capability of outstanding early career researchers. This award will enable Dr Bonder to expand her excellent work on the molecular basis of vascular disease.

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CCB Co-Director Professor Angel Lopez wins ‘South Australian Scientist of the Year’ award

13th August 2010

This most prestigious science award in South Australia was shared by Professor Lopez and Professor Monro (University of Adelaide). For almost 25 years Professor Lopez's research has focused on cytokines that regulate blood cell production and function. The South Australian Scientist of the Year award recognizes many seminal discoveries of Professor Lopez that have led to the better understanding of the functioning of cytokines and cytokine receptors networks in normal physiology and in diseases such as leukemia and asthma. His group’s work has also led to new paradigms of cytokine receptor signaling, leading to the development of new therapeutics.

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CCB awarded $3.5 million by the ACRF

30th November 2009

ACRF logo

The CCB was one of two winners of the 2009 round of applications for capital equiment by the Australian Cancer Research Foundation. In conjunction with researchers from the University of Adelaide , the CCB successfully won a bid for $3.5 million to establish the South Australia Cancer Genomics Facility. This new state-of-the-art Facility will facilitate discovery and innovation by CCB researchers and help their translational efforts in developing better diagnostics and more effective anti-cancer drugs.

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Fourth Barossa Meeting successfully ended today

21st November 2009

The Fourth Barossa “Science Among the Vines” Meeting on Cell Signalling in Cancer and Development, organised by members of the Centre for Cancer Biology, took place 18-21 November 2009 at the Novotel Barossa Valley.

The “Science Among the Vines” meeting was highly successful, being described by some notable attendees as “Australia’s best conference”. This is no doubt a reflection of the superb program that showcased 12 invited international speakers, 20 invited national speakers and 6 speakers from the Centre for Cancer Biology. The participants at this fully subscribed conference also enjoyed the culinary delights of the famous Barossa Valley. A full report on the meeting will be published shortly in Cancer Research.

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2009 Clifford Prize for Cancer Research awarded to Prof John Dick of Toronto

19th November 2009

Today, as part of the Fourth Barossa Meeting, Prof John Dick, Director of the Program in Cancer Stem Cells at the Ontario Institute for Cancer Research, University of Toronto was awarded the 2009 Clifford Prize for Cancer Research.

John Dick’s groundbreaking work on cancer stem cells has transformed our view of cancer pathogenesis. His discovery that, similar to the normal hemopoietic system, leukaemias are composed of both stem cells and more differentiated cells is a key new insight into cancer development. The concepts that have emerged from his research are now being applied, by his lab and others, to solid tumour biology, where they have the potential for even greater conceptual and medical impact

The prize comprises a perpetual trophy in the form of an ad hominem glass sculpture (donated by Johnson & Johnson) made by Nick Mount, and a magnum of Penfolds Grange Hermitage, arguably Australia‘s finest wine (donated by Penfolds).

This year’s prize was awarded by a committee co-chaired by Professors Angel Lopez, SA Pathology, Adelaide and Mathew Vadas, Centenary Institute, Sydney. Committee members included Professors Donald Metcalf, Walter and Eliza Hall Institute, Melbourne; Robert Sutherland, Garvan Institute, Sydney; Christopher Goodnow, John Curtin School of Medical Research, Canberra; Axel Ullrich (2005 recipient), Max Planck Institute, Munich and Tony Hunter (2007 recipient), Salk Institute, La Jolla.

Dr David Filby of the Dept of Health of South Australia (left) presenting the award to Prof John Dick

From Left to Right Prof Mathew Vadas (ED Centenary Institute, Sydney), Mr Terry Evans (Chairman MedVet Board), Prof Ruth Salom (ED SA Pathology), Prof John Dick (Director of the Program in Cancer Stem Cells at the Ontario Institute for Cancer Research) Prof Angel Lopez (co-Director Centre for Cancer Biology of SA Pathology)

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CCB Members win NHMRC grants

11th November 2009

NHMRC Fellowships

  • Michael Beard received an NHMRC Senior Research Fellowship.
    (2010-2014) $560,000

NHMRC Career Development Awards

  • Quenten Schwarz received an NHMRC Career Development Award.
    (2010-2014) $377,000
  • Michele Grimbaldston received an NHMRC Career Development Award.
    (2010-2014) $377,000

NHMRC Project Grants

  • Richard D’Andrea:
    received $588,500 for research into the “KLF5 function in normal and leukaemic haemopoiesis”. (R D’Andrea, C Mullighan, I Lewis and N Jenkins) 2010-2012

    received $562,500 for research into the “Dissecting the role of the IL-3 receptor alpha subunit and beta-catenin in Acute Myeloid Leukaemia”. (R D’Andrea, H Ramshaw, P Ekert, I Lewis, S Barry) 2010-2012


  • Mark Guthridge:
    received $415,125 grant for research of “Regulation of pleiotropic responses by binary switches embedded in the Fibroblast Growth Factor Receptors”. (M Guthridge) 2010-2012


  • Natasha Harvey:
    received $535,500 for research of “Defining the molecular events that initiate the genesis of lymphatic vessels”. (N Harvey & M Francois) 2010-2012


  • Yeesim Khew-Goodall:
    received $514,500 for research of “The Pez-TGFß-miR200-ZEB1/2 axis in breast cancer”. (Y Khew-Goodall, G Goodall, & G Farshid) 2010-2012

    received $415,500 for research into the “Identification of microRNAs in Scleroderma”. (Y Khew-Goodall, G Goodall, & G Farshid) 2010-2012


  • Sharad Kumar:
    received $502,500 for research into “Transcription control of cell death and proliferation”. (S Kumar) 2010-2012

    received $583,500 for research of “A novel tumour suppressor”. (S Kumar) 2010-2012

    received $484,500 for research into the “Novel modes of cell death during development”. (S Kumar, E H Baehrecke & L Dorstyn) 2010-2012


  • Stuart Pitson:
    received $499,500 for research of the “Mechanisms of regulation and biological roles of sphingosine kinase 2”. (S Pitson) 2010-2012

    received $504,500 for research into the “Role of sphingosine kinase 1 in PP2A-associated tumorigenesis”. (S Pitson) 2010-2012


  • Andrew Zannettino:
    received $583,500 for research of “Is hypoxia inducible factor 2 the trigger of angiogenic switch and a driver of disease progression in myeloma”. (A Zannettino) 2010-2012

ARC Discovery Project Grant

  • Angel Lopez:
    received $330,000 for research into the “Structural and functional characterisation of PI3Kgamma, uniquely activated by p101”. (Prof SR McColl & Prof AF Lopez) 2010-2012

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Dr Deb White (Associate Member CCB) has been awarded a Translational Grant from the Leukemia Lymphoma Society of America for her project entitled:-The role of OCT-1 Activity enhancers in improving the response of patients with low OCT-1 activity to imatinib.


15th July 2009

This Grant is for the period October 1, 2009 through September 30, 2012 and provides a maximum of $US200,000 per year. The studies proposed in this Grant are a continuation of the successful research completed to date by Dr White and Professor Hughes, and aim to improve treatment outcomes for those patients with Chronic Myeloid Leukaemia who respond poorly to imatinib (front line treatment for this disease).

Associate Investigators on this Grant are Professor Tim Hughes (Member CCB) A/Professor Richard D’Andrea (Member CCB), Professor Andrew Somogyi and Professor Junia Melo (Member CCB).

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Launch of the new Centre for Cancer Biology here in SA Pathology


16th April 2009

The highlight of today is the launch of the new Centre for Cancer Biology here in SA Pathology. The Centre currently has 15 research groups and 154 staff and students, most of which are supported by peer reviewed funding brought in by the members of the CCB.

The CCB was officially opened by Prof Ian Frazer FAA, Director of Diamantina Institute, on April 16, 2009. In the photo (from left to right): Prof Sharad Kumar, Prof Angel Lopez, Prof Ian Frazer, Hon John Hill (S.A. Minister for Heath), Prof Ruth Salom (Executive Director, SA Pathology), Dr Tony Sherbon (Chief Executive Officer, S.A. Department of Health)

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Centre for Cancer Biology awarded $3.7 million


Prime Minister of Australia - Media Release


20th January 2009


Prime Minister Kevin Rudd today announced $5.6 million in funding for new research and clinical trial initiatives to reduce the impact of cancer on all Australians.

In South Australia, the Institute of Medical and Veterinary Science (IMVS) will receive $3.7 million in National Health and Medical Research Council Program Grant funding for its work on better treatment for blood cell cancers such as leukaemia, and inflammatory diseases.

Professor Angel Lopez, head of the human immunology research team at IMVS and co-head of the newly-formed SA Centre for Cancer Biology, will lead the research, which focuses on a group of protein hormones and their receptors which are implicated in blood cell cancers such as leukaemia and inflammatory diseases for which current treatments are inadequate.

Prof Lopez’s research will help Australia develop new drugs which are more specific to cancers such as leukaemia, and have fewer side effects.

The program funding is spread over five years starting in 2010 and will support the Centre, which has about 120 staff.

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