Latest publication by Jantina Manning and Sharad Kumar in TIBS this month
Latest publication by Jantina Manning and Sharad Kumar in TIBS this month

Latest publication by Jantina Manning and Sharad Kumar in TIBS this month

Highlights of this review paper "Physiological Functions of Nedd4-2: Lessons from Knockout Mouse Models" Trends in Biochemical Sciences  Vol 43, Issue 8, August 2018, Pages 635-647.

  • Nedd4-2 (also called NEDD4L) is a HECT-type ubiquitin ligase that is involved in the regulation of multiple membrane proteins.
  • Nedd4-2 is likely to influence multiple signaling networks via specific targeting of proteins in different tissues, and variants in human NEDD4L are associated with developmental disorders, hypertension, and end-stage renal disorders.
  • Mouse knockout studies indicate that Nedd4-2 is a key regulator of Na+ homeostasis, and ENaC is one of its most important physiological substrates.
  • Pathological consequences of dysregulated Nedd4-2 in mice include disorders of the respiratory, renal, cardiac, neural, and immune systems.
  • Observation that Nedd4-2 deficiency causes kidney disease provides a link between dysregulated Na+ reabsorption and renal tubular injury.